8/n🧵Having shown that base editors can both inactivate tumor suppressors (PTEN) and over-activate oncogenes CTNNB1 we sought to combine the two. To do this we were inspired by the work of Jarno Drost, a previous PostDoc in the lab. Read more: https://t.co/
If I'm reading about colorectal cancer, you know I'm reading for class again. Is cancer just gene dysregulation? A two part series in which researchers try to make cancer from scratch. This time from cultured intestinal stem cell organoids! https://t.co/eE
Sequential cancer mutations in cultured human intestinal stem cells. - PubMed - NCBI https://t.co/XeEfqPiFvj
Awe inspiring live cell imaging of chromosome segregations in human intestinal stem cell organoids. Cool stuff :) http://t.co/JuOD5HEETz