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Meniscus repair using mesenchymal stem cells – a comprehensive review

Overview of attention for article published in Stem Cell Research & Therapy, April 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
4 X users

Citations

dimensions_citation
74 Dimensions

Readers on

mendeley
198 Mendeley
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Title
Meniscus repair using mesenchymal stem cells – a comprehensive review
Published in
Stem Cell Research & Therapy, April 2015
DOI 10.1186/s13287-015-0077-2
Pubmed ID
Authors

Hana Yu, Adetola B Adesida, Nadr M Jomha

Abstract

The menisci are a pair of semilunar fibrocartilage structures that play an essential role in maintaining normal knee function. Injury to the menisci can disrupt joint stability and lead to debilitating results. Because natural meniscal healing is limited, an efficient method of repair is necessary. Tissue engineering (TE) combines the principles of life sciences and engineering to restore the unique architecture of the native meniscus. Mesenchymal stem cells (MSCs) have been investigated for their therapeutic potential both in vitro and in vivo. This comprehensive review examines the English literature identified through a database search using Medline, Embase, Engineering Village, and SPORTDiscus. The search results were classified based on MSC type, animal model, and method of MSC delivery/culture. A variety of MSC types, including bone marrow-derived, synovium-derived, adipose-derived, and meniscus-derived MSCs, has been examined. Research results were categorized into and discussed by the different animal models used; namely murine, leporine, porcine, caprine, bovine, ovine, canine, equine, and human models of meniscus defect/repair. Within each animal model, studies were categorized further according to MSC delivery/culture techniques. These techniques included direct application, fibrin glue/gel/clot, intra-articular injection, scaffold, tissue-engineered construct, meniscus tissue, pellets/aggregates, and hydrogel. The purpose of this review is to inform the reader about the current state and advances in meniscus TE using MSCs. Future directions of MSC-based meniscus TE are also suggested to help guide prospective research.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Malaysia 1 <1%
Korea, Republic of 1 <1%
United Kingdom 1 <1%
Brazil 1 <1%
Denmark 1 <1%
New Zealand 1 <1%
Unknown 190 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 28 14%
Student > Ph. D. Student 26 13%
Student > Bachelor 24 12%
Student > Master 22 11%
Student > Doctoral Student 15 8%
Other 37 19%
Unknown 46 23%
Readers by discipline Count As %
Medicine and Dentistry 56 28%
Agricultural and Biological Sciences 24 12%
Biochemistry, Genetics and Molecular Biology 16 8%
Engineering 14 7%
Veterinary Science and Veterinary Medicine 8 4%
Other 23 12%
Unknown 57 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2017.
All research outputs
#1,847,723
of 22,800,560 outputs
Outputs from Stem Cell Research & Therapy
#115
of 2,418 outputs
Outputs of similar age
#25,321
of 263,976 outputs
Outputs of similar age from Stem Cell Research & Therapy
#4
of 65 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,976 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.