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Cardiolipin Remodeling by TAZ/Tafazzin Is Selectively Required for the Initiation of Mitophagy.

Overview of attention for article published in Autophagy, April 2015
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  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
2 tweeters
facebook
1 Facebook page

Citations

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40 Dimensions

Readers on

mendeley
38 Mendeley
Title
Cardiolipin Remodeling by TAZ/Tafazzin Is Selectively Required for the Initiation of Mitophagy.
Published in
Autophagy, April 2015
DOI 10.1080/15548627.2015.1023984
Pubmed ID
Authors

Paul Hsu, Hsu, Paul, Liu, Xiaolei, Zhang, Jun, Wang, Hong-Gang, Ye, Ji-Ming, Shi, Yuguang

Abstract

Tafazzin (TAZ) is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Mutations of TAZ cause Barth syndrome, which is characterized by mitochondrial dysfunction and dilated cardiomyopathy, leading to premature death. However, the molecular mechanisms underlying the cause of mitochondrial dysfunction in Barth syndrome remain poorly understood. Here we investigated the role of TAZ in regulating mitochondrial function and mitophagy. Using primary mouse embryonic fibroblasts (MEFs) with doxycycline-inducible knockdown of Taz, we showed that TAZ deficiency in MEFs caused defective mitophagosome biogenesis, but not other autophagic processes. Consistent with a key role of mitophagy in mitochondria quality control, TAZ deficiency in MEFs also led to impaired oxidative phosphorylation and severe oxidative stress. Together, these findings provide key insights on mitochondrial dysfunction in Barth syndrome, suggesting that pharmacological restoration of mitophagy may provide a novel treatment for this lethal condition.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 5%
Unknown 36 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 21%
Researcher 5 13%
Student > Master 4 11%
Student > Bachelor 3 8%
Professor > Associate Professor 3 8%
Other 10 26%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 29%
Biochemistry, Genetics and Molecular Biology 10 26%
Medicine and Dentistry 3 8%
Physics and Astronomy 2 5%
Psychology 1 3%
Other 4 11%
Unknown 7 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2015.
All research outputs
#2,310,964
of 5,042,283 outputs
Outputs from Autophagy
#211
of 756 outputs
Outputs of similar age
#75,680
of 156,209 outputs
Outputs of similar age from Autophagy
#9
of 45 outputs
Altmetric has tracked 5,042,283 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 756 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,209 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.