The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study

@NiuSanford @5_utr Cool 👍 as you know… the more stats you know the scarier the literature becomes. I was thinking about writing a Stats for the people on this topic looking at the PREMER HA PCI trial. I also would read this great paper by @VickersBiostats

@TomKealy2 Might be worth checking out this paper by @VickersBiostats https://t.co/07NX79trKQ. The recommendation in biostats circles is to basically always use ANCOVA

@GMFHx @HedonicMicrobes I have some concerns about this study. Firstly, they reported a non-significant result (-2.27±0.92kg, P=0.09) as a "slightly decreased body weight" - a red flag for suggesting the effect. Moreover, % change from baseline is not a re

@PloederlM @IoanaA_Cristea @David_NeverDave Indeed, he shows that, if any approach is fatally flawed here, it's change from baseline and percentage change. Reduces power, becomes weird if variances change, etc. The field really should stick to post-treatme