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Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas

Overview of attention for article published in Diagnostic Pathology, April 2015
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Title
Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas
Published in
Diagnostic Pathology, April 2015
DOI 10.1186/s13000-015-0268-2
Pubmed ID
Authors

Ana Cristina Lira Sobral, Victor Moreschi Neto, Gabriela Traiano, Ana Paula Percicote, Elizabeth Schneider Gugelmin, Cleber Machado de Souza, Lia Nakao, Luiz Fernando Bleggi Torres, Lucia de Noronha

Abstract

Medulloblastoma is a malignant, invasive embryonal tumor of the cerebellum and accounts for 20% of intracranial tumors in children. QSOX1, whose functions include formation of disulphide bridges, which are needed for correct protein folding and stability, formation of the extracellular matrix, regulation of the redox status and cell cycle control, appears to be involved in apoptosis in pathological states such as cancer. Thus, the aim of this study was to investigate the immunohistochemical expression of QSOX1 in medulloblastomas and nonneoplastic cerebellum. Histology blocks of pediatric medulloblastomas were separated and two representative areas of the tumors and non-neoplastic cerebellum samples were used to construct tissue microarrays (TMAs) that were stained with an anti-QSOX1 antibody, and the slides were read using image analysis software. QSOX1 immunoexpression was observed in the non-neoplastic cerebellum samples and the medulloblastoma samples. There was no statistically significant relationship between QSOX1 immunopositivity in the medulloblastoma samples and the clinical and pathological variables. Although QSOX1 did not prove useful for stratifying patients into risk groups, tumor cells and the fibrillar extracellular matrix were positive for this marker, indicating that this enzyme may be involved in the pathogenesis of medulloblastoma. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1822040654139436.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 29%
Student > Master 3 21%
Student > Postgraduate 2 14%
Researcher 2 14%
Professor > Associate Professor 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 36%
Computer Science 1 7%
Unspecified 1 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Immunology and Microbiology 1 7%
Other 3 21%
Unknown 2 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2015.
All research outputs
#10,214,033
of 12,786,839 outputs
Outputs from Diagnostic Pathology
#498
of 793 outputs
Outputs of similar age
#156,326
of 226,196 outputs
Outputs of similar age from Diagnostic Pathology
#2
of 3 outputs
Altmetric has tracked 12,786,839 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 793 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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