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Melatonin prevents hyperglycemia in a model of sleep apnea

Overview of attention for article published in Archives of Endocrinology and Metabolism, February 2015
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3 tweeters

Citations

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8 Dimensions

Readers on

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43 Mendeley
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Title
Melatonin prevents hyperglycemia in a model of sleep apnea
Published in
Archives of Endocrinology and Metabolism, February 2015
DOI 10.1590/2359-3997000000012
Pubmed ID
Authors

Renata Schenkel Rivera Kaminski, Denis Martinez, Micheli Fagundes, Emerson Ferreira Martins, Carolina Caruccio Montanari, Darlan Pase Rosa, Cintia Zappe Fiori, Norma Possa Marroni

Abstract

Objective Obstructive sleep apnea is a common disorder associated with aging and obesity. Apneas cause repeated arousals, intermittent hypoxia, and oxidative stress. Changes in glucolipidic profile occur in apnea patients, independently of obesity. Animal models of sleep apnea induce hyperglycemia. This study aims to evaluate the effect of the antioxidants melatonin and N-acetylcysteine on glucose, triglyceride, and cholesterol levels in animals exposed to intermittent hypoxia. Materials and methods Two groups of Balb/c mice were exposed to intermittent hypoxia (n = 36) or sham intermittent hypoxia (n = 36) for 35 days. The intermittent hypoxia group underwent a total of 480 cycles of 30 seconds reducing the inspired oxygen fraction from 21% to 7 ± 1% followed by 30 seconds of normoxia, during 8 hours daily. Melatonin or N-acetylcysteine were injected intraperitonially daily from day 21 on. Results At day 35, glucose levels were significantly higher in the intermittent hypoxia group than in the control group. The intermittent hypoxia groups receiving N-acetylcysteine and vehicle showed higher glucose levels than the group receiving melatonin. The lipid profile was not affected by intermittent hypoxia or antioxidant administration. Conclusions The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia. Further exploration of the role of melatonin in sleep apnea is warranted. Arch Endocrinol Metab. 2015;59(1):66-70.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 5%
United Kingdom 1 2%
Unknown 40 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 21%
Researcher 7 16%
Student > Master 7 16%
Student > Doctoral Student 5 12%
Unspecified 2 5%
Other 6 14%
Unknown 7 16%
Readers by discipline Count As %
Medicine and Dentistry 14 33%
Agricultural and Biological Sciences 5 12%
Neuroscience 4 9%
Nursing and Health Professions 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 9 21%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2015.
All research outputs
#11,488,640
of 19,211,930 outputs
Outputs from Archives of Endocrinology and Metabolism
#55
of 184 outputs
Outputs of similar age
#114,793
of 239,835 outputs
Outputs of similar age from Archives of Endocrinology and Metabolism
#4
of 7 outputs
Altmetric has tracked 19,211,930 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 184 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,835 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.