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The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies

Overview of attention for article published in Cancer Immunology Research, May 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
2 news outlets
twitter
2 tweeters
patent
3 patents

Citations

dimensions_citation
477 Dimensions

Readers on

mendeley
452 Mendeley
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Title
The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential Synergies
Published in
Cancer Immunology Research, May 2015
DOI 10.1158/2326-6066.cir-15-0064
Pubmed ID
Authors

Leisha A. Emens, Gary Middleton

Abstract

Although cancer chemotherapy has historically been considered immune suppressive, it is now accepted that certain chemotherapies can augment tumor immunity. The recent success of immune checkpoint inhibitors has renewed interest in immunotherapies, and in combining them with chemotherapy to achieve additive or synergistic clinical activity. Two major ways that chemotherapy promotes tumor immunity are by inducing immunogenic cell death as part of its intended therapeutic effect and by disrupting strategies that tumors use to evade immune recognition. This second strategy, in particular, is dependent on the drug, its dose, and the schedule of chemotherapy administration in relation to antigen exposure or release. In this Cancer Immunology at the Crossroads article, we focus on cancer vaccines and immune checkpoint blockade as a forum for reviewing preclinical and clinical data demonstrating the interplay between immunotherapy and chemotherapy. Cancer Immunol Res; 3(5); 436-43. ©2015 AACR.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 452 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
United Kingdom 1 <1%
Korea, Republic of 1 <1%
United States 1 <1%
Philippines 1 <1%
Unknown 447 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 88 19%
Researcher 80 18%
Student > Bachelor 45 10%
Student > Master 39 9%
Other 37 8%
Other 66 15%
Unknown 97 21%
Readers by discipline Count As %
Medicine and Dentistry 102 23%
Biochemistry, Genetics and Molecular Biology 57 13%
Agricultural and Biological Sciences 48 11%
Immunology and Microbiology 47 10%
Pharmacology, Toxicology and Pharmaceutical Science 23 5%
Other 51 11%
Unknown 124 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2022.
All research outputs
#1,200,195
of 22,113,391 outputs
Outputs from Cancer Immunology Research
#113
of 1,358 outputs
Outputs of similar age
#16,478
of 246,166 outputs
Outputs of similar age from Cancer Immunology Research
#4
of 41 outputs
Altmetric has tracked 22,113,391 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,358 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.