Title |
Healthy eating and reduced risk of cognitive decline
|
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Published in |
Neurology, May 2015
|
DOI | 10.1212/wnl.0000000000001638 |
Pubmed ID | |
Authors |
Andrew Smyth, Mahshid Dehghan, Martin O'Donnell, Craig Anderson, Koon Teo, Peggy Gao, Peter Sleight, Gilles Dagenais, Jeffrey L. Probstfield, Andrew Mente, Salim Yusuf, Salim Yusuf, Rafael Diaz, Leopoldo Piegas, Koon Teo, Gilles Dagenais, Ernesto Cardona, Jeffrey Probstfield, Michael Weber, James Young, Robert Fagard, Jean Mallion, Johannes Mann, Michael Bohm, Nicholas Karatzas, Matyas Keltai, Bruno Trimarco, Paolo Verdecchia, Leszek Ceremuzynski, Andrzej Budaj, Rafael Ferreira, Irina Chazova, Lars Ryden, George Fodor, Patrick Commerford, Josep Redon, Thomas Luescher, Ali Oto, Azan Binbrek, Peter Sleight, Alexander Parkhomenko, Garry Jennings, Lisheng Liu, John Sanderson, Chin Choy Lang, Jae-Hyung Kim, Jyh-Hong Chen, Suphachai Chaithiraphan, Petr Jansky, Ernesto Paolasso, Alvaro Avezum, Bernd Eber, Aldo Maggioni, Giuseppe Mancia, Nicholas Holwerda, Tage Lysbo Svendsen, Kaj Metsarinne, Kenneth Dickstein, Bernark Kwok |
Abstract |
We sought to determine the association of dietary factors and risk of cognitive decline in a population at high risk of cardiovascular disease. Baseline dietary intake and measures of the Mini-Mental State Examination were recorded in 27,860 men and women who were enrolled in 2 international parallel trials of the ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease) studies. We measured diet quality using the modified Alternative Healthy Eating Index. Cox proportional hazards regression was used to determine the association between diet quality and risk of ≥3-point decline in Mini-Mental State Examination score, and reported as hazard ratio with 95% confidence intervals with adjustment for covariates. During 56 months of follow-up, 4,699 cases of cognitive decline occurred. We observed lower risk of cognitive decline among those in the healthiest dietary quintile of modified Alternative Healthy Eating Index compared with lowest quintile (hazard ratio 0.76, 95% confidence interval 0.66-0.86, Q5 vs Q1). Lower risk of cognitive decline was consistent regardless of baseline cognitive level. We found that higher diet quality was associated with a reduced risk of cognitive decline. Improved diet quality represents an important potential target for reducing the global burden of cognitive decline. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 21 | 23% |
United Kingdom | 12 | 13% |
Spain | 10 | 11% |
Canada | 4 | 4% |
Ireland | 2 | 2% |
France | 2 | 2% |
Brazil | 1 | 1% |
India | 1 | 1% |
Costa Rica | 1 | 1% |
Other | 8 | 9% |
Unknown | 30 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 67 | 73% |
Scientists | 14 | 15% |
Practitioners (doctors, other healthcare professionals) | 8 | 9% |
Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 112 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 25 | 22% |
Researcher | 16 | 14% |
Student > Bachelor | 11 | 10% |
Professor | 8 | 7% |
Student > Ph. D. Student | 7 | 6% |
Other | 19 | 17% |
Unknown | 26 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 28% |
Biochemistry, Genetics and Molecular Biology | 7 | 6% |
Nursing and Health Professions | 6 | 5% |
Neuroscience | 6 | 5% |
Psychology | 6 | 5% |
Other | 15 | 13% |
Unknown | 41 | 37% |