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Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil

Overview of attention for article published in Revista da Sociedade Brasileira de Medicina Tropical, February 2015
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Title
Seroprevalence and seroincidence of Leptospira infection in dogs during a one-year period in an endemic urban area in Southern Brazil
Published in
Revista da Sociedade Brasileira de Medicina Tropical, February 2015
DOI 10.1590/0037-8682-0213-2014
Pubmed ID
Authors

Vivien Midori Morikawa, Daniele Bier, Maysa Pellizzaro, Leila Sabrina Ullmann, Igor Adolfo Dexheimer Paploski, Mariana Kikuti, Hélio Langoni, Alexander Welker Biondo, Marcelo Beltrão Molento

Abstract

Leptospirosis is a zoonosis that affects both humans and animals. Dogs may serve as sentinels and indicators of environmental contamination as well as potential carriers for Leptospira. This study aimed to evaluate the seroprevalence and seroincidence of leptospirosis infection in dogs in an urban low-income community in southern Brazil where human leptospirosis is endemic. A prospective cohort study was designed that consisted of sampling at recruitment and four consecutive trimestral follow-up sampling trials. All households in the area were visited, and those that owned dogs were invited to participate in the study. The seroprevalence (MAT titers ≥100) of Leptospira infection in dogs was calculated for each visit, the seroincidence (seroconversion or four-fold increase in serogroup-specific MAT titer) density rate was calculated for each follow-up, and a global seroincidence density rate was calculated for the overall period. A total of 378 dogs and 902.7 dog-trimesters were recruited and followed, respectively. The seroprevalence of infection ranged from 9.3% (95% CI; 6.7 - 12.6) to 19% (14.1 - 25.2), the seroincidence density rate of infection ranged from 6% (3.3 - 10.6) to 15.3% (10.8 - 21.2), and the global seroincidence density rate of infection was 11% (9.1 - 13.2) per dog-trimester. Canicola and Icterohaemorraghiae were the most frequent incident serogroups observed in all follow-ups. Follow-ups with mean trimester intervals were incapable of detecting any increase in seroprevalence due to seroincident cases of canine leptospirosis, suggesting that antibody titers may fall within three months. Further studies on incident infections, disease burden or risk factors for incident Leptospira cases should take into account the detectable lifespan of the antibody.

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Mendeley readers

The data shown below were compiled from readership statistics for 267 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 6 2%
Unknown 261 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 60 22%
Student > Doctoral Student 34 13%
Student > Postgraduate 29 11%
Student > Bachelor 27 10%
Student > Ph. D. Student 19 7%
Other 45 17%
Unknown 53 20%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 87 33%
Agricultural and Biological Sciences 50 19%
Medicine and Dentistry 31 12%
Biochemistry, Genetics and Molecular Biology 9 3%
Immunology and Microbiology 5 2%
Other 23 9%
Unknown 62 23%