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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure-based drug design studies of the interactions ofent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparumsarco/endoplasmic reticulum Ca2+-ATPase PfATP6
|
|---|---|
| Published in |
Memórias do Instituto Oswaldo Cruz, April 2015
|
| DOI | 10.1590/0074-02760140415 |
| Pubmed ID | |
| Authors |
Daniel Silqueira Martins Guimarães, Amanda Luisa da Fonseca, Ronan Batista, Moacyr Comar, Alaíde Braga de Oliveira, Alex Gutterres Taranto, Fernando de Pilla Varotti |
| Abstract |
Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance. Semisynthetic compounds derived from diterpenes from the medicinal plant Wedelia paludosa were tested in silico against the Plasmodium falciparum Ca2+-ATPase, PfATP6. This protein was constructed by comparative modelling using the three-dimensional structure of a homologous protein, 1IWO, as a scaffold. Compound 21 showed the best docking scores, indicating a better interaction with PfATP6 than that of thapsigargin, the natural inhibitor. Inhibition of PfATP6 by diterpene compounds could promote a change in calcium homeostasis, leading to parasite death. These data suggest PfATP6 as a potential target for the antimalarial ent-kaurane diterpenes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Burkina Faso | 1 | 2% |
| Unknown | 49 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 22% |
| Student > Ph. D. Student | 8 | 16% |
| Student > Master | 6 | 12% |
| Researcher | 5 | 10% |
| Professor | 4 | 8% |
| Other | 6 | 12% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 12 | 24% |
| Biochemistry, Genetics and Molecular Biology | 7 | 14% |
| Medicine and Dentistry | 6 | 12% |
| Agricultural and Biological Sciences | 5 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Other | 4 | 8% |
| Unknown | 13 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2015.
All research outputs
#16,721,208
of 25,371,288 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#975
of 1,502 outputs
Outputs of similar age
#161,140
of 279,164 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#16
of 29 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,502 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,164 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.