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Structure-based drug design studies of the interactions ofent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparumsarco/endoplasmic reticulum Ca2+-ATPase PfATP6

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, April 2015
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Mentioned by

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2 tweeters

Citations

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10 Dimensions

Readers on

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45 Mendeley
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Title
Structure-based drug design studies of the interactions ofent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparumsarco/endoplasmic reticulum Ca2+-ATPase PfATP6
Published in
Memórias do Instituto Oswaldo Cruz, April 2015
DOI 10.1590/0074-02760140415
Pubmed ID
Authors

Daniel Silqueira Martins Guimarães, Amanda Luisa da Fonseca, Ronan Batista, Moacyr Comar Junior, Alaíde Braga de Oliveira, Alex Gutterres Taranto, Fernando de Pilla Varotti

Abstract

Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance. Semisynthetic compounds derived from diterpenes from the medicinal plant Wedelia paludosa were tested in silico against the Plasmodium falciparum Ca2+-ATPase, PfATP6. This protein was constructed by comparative modelling using the three-dimensional structure of a homologous protein, 1IWO, as a scaffold. Compound 21 showed the best docking scores, indicating a better interaction with PfATP6 than that of thapsigargin, the natural inhibitor. Inhibition of PfATP6 by diterpene compounds could promote a change in calcium homeostasis, leading to parasite death. These data suggest PfATP6 as a potential target for the antimalarial ent-kaurane diterpenes.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Burkina Faso 1 2%
Unknown 43 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 22%
Student > Ph. D. Student 9 20%
Student > Master 5 11%
Professor 4 9%
Researcher 4 9%
Other 7 16%
Unknown 6 13%
Readers by discipline Count As %
Chemistry 12 27%
Biochemistry, Genetics and Molecular Biology 6 13%
Medicine and Dentistry 6 13%
Agricultural and Biological Sciences 5 11%
Computer Science 2 4%
Other 4 9%
Unknown 10 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2015.
All research outputs
#7,544,821
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#565
of 862 outputs
Outputs of similar age
#112,544
of 227,665 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#8
of 13 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,665 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.