Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial

Overview of attention for article published in JAMA Internal Medicine, May 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#26 of 2,436)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

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51 news outlets
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13 blogs
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804 tweeters
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88 Facebook pages
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17 Google+ users
reddit
3 Redditors
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1 video uploader

Readers on

mendeley
59 Mendeley
Title
Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial
Published in
JAMA Internal Medicine, May 2015
DOI 10.1001/jamainternmed.2015.1668
Pubmed ID
Authors

Cinta Valls-Pedret, Aleix Sala-Vila, Mercè Serra-Mir, Dolores Corella, Rafael de la Torre, Miguel Ángel Martínez-González, Elena H. Martínez-Lapiscina, Montserrat Fitó, Ana Pérez-Heras, Jordi Salas-Salvadó, Ramon Estruch, Emilio Ros, Valls-Pedret, Cinta, Sala-Vila, Aleix, Serra-Mir, Mercè, Corella, Dolores, de la Torre, Rafael, Martínez-González, Miguel Ángel, Martínez-Lapiscina, Elena H, Fitó, Montserrat, Pérez-Heras, Ana, Salas-Salvadó, Jordi, Estruch, Ramon, Ros, Emilio

Abstract

Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia. Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline, but clinical trial evidence is lacking. To investigate whether a Mediterranean diet supplemented with antioxidant-rich foods influences cognitive function compared with a control diet. Parallel-group randomized clinical trial of 447 cognitively healthy volunteers from Barcelona, Spain (233 women [52.1%]; mean age, 66.9 years), at high cardiovascular risk were enrolled into the Prevención con Dieta Mediterránea nutrition intervention trial from October 1, 2003, through December 31, 2009. All patients underwent neuropsychological assessment at inclusion and were offered retesting at the end of the study. Participants were randomly assigned to a Mediterranean diet supplemented with extravirgin olive oil (1 L/wk), a Mediterranean diet supplemented with mixed nuts (30 g/d), or a control diet (advice to reduce dietary fat). Rates of cognitive change over time based on a neuropsychological test battery: Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT), Animals Semantic Fluency, Digit Span subtest from the Wechsler Adult Intelligence Scale, Verbal Paired Associates from the Wechsler Memory Scale, and the Color Trail Test. We used mean z scores of change in each test to construct 3 cognitive composites: memory, frontal (attention and executive function), and global. Follow-up cognitive tests were available in 334 participants after intervention (median, 4.1 years). In multivariate analyses adjusted for confounders, participants allocated to a Mediterranean diet plus olive oil scored better on the RAVLT (P = .049) and Color Trail Test part 2 (P = .04) compared with controls; no between-group differences were observed for the other cognitive tests. Similarly adjusted cognitive composites (mean z scores with 95% CIs) for changes above baseline of the memory composite were 0.04 (-0.09 to 0.18) for the Mediterranean diet plus olive oil, 0.09 (-0.05 to 0.23; P = .04 vs controls) for the Mediterranean diet plus nuts, and -0.17 (-0.32 to -0.01) for the control diet. Respective changes from baseline of the frontal cognition composite were 0.23 (0.03 to 0.43; P = .003 vs controls), 0.03 (-0.25 to 0.31), and -0.33 (-0.57 to -0.09). Changes from baseline of the global cognition composite were 0.05 (-0.11 to 0.21; P = .005 vs controls) for the Mediterranean diet plus olive oil, -0.05 (-0.27 to 0.18) for the Mediterranean diet plus nuts, and -0.38 (-0.57 to -0.18) for the control diet. All cognitive composites significantly (P < .05) decreased from baseline in controls. In an older population, a Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function. isrctn.org Identifier: ISRCTN35739639.

Twitter Demographics

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Mendeley readers

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Geographical breakdown

Country Count As %
Spain 1 2%
Brazil 1 2%
Philippines 1 2%
Canada 1 2%
Unknown 55 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 25%
Student > Ph. D. Student 10 17%
Student > Master 9 15%
Professor > Associate Professor 7 12%
Student > Bachelor 5 8%
Other 13 22%
Readers by discipline Count As %
Medicine and Dentistry 26 44%
Agricultural and Biological Sciences 13 22%
Psychology 8 14%
Biochemistry, Genetics and Molecular Biology 4 7%
Social Sciences 2 3%
Other 6 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1094. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2017.
All research outputs
#1,106
of 7,424,936 outputs
Outputs from JAMA Internal Medicine
#26
of 2,436 outputs
Outputs of similar age
#45
of 204,554 outputs
Outputs of similar age from JAMA Internal Medicine
#2
of 162 outputs
Altmetric has tracked 7,424,936 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,436 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 101.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,554 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.