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Tamoxifen and Flaxseed Alter Angiogenesis Regulators in Normal Human Breast Tissue In Vivo.

Overview of attention for article published in PLoS ONE, January 2011
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Title
Tamoxifen and Flaxseed Alter Angiogenesis Regulators in Normal Human Breast Tissue In Vivo.
Published in
PLoS ONE, January 2011
DOI 10.1371/journal.pone.0025720
Pubmed ID
Authors

Ulrika W. Nilsson Åberg, Niina Saarinen, Annelie Abrahamsson, Tarja Nurmi, Sofia Engblom, Charlotta Dabrosin, Jean-Marc A. Lobaccaro

Abstract

The incidence of breast cancer is increasing in the Western world and there is an urgent need for studies of the mechanisms of sex steroids in order to develop novel preventive strategies. Diet modifications may be among the means for breast cancer prevention. Angiogenesis, key in tumor progression, is regulated by the balance between pro- and anti-angiogenic factors, which are controlled in the extracellular space. Sampling of these molecules at their bioactive compartment is therefore needed. The aims of this study were to explore if tamoxifen, one of the most used anti-estrogen treatments for breast cancer affected some of the most important endogenous angiogenesis regulators, vascular endothelial growth factor (VEGF), angiogenin, and endostatin in normal breast tissue in vivo and if a diet supplementation with flaxseed had similar effects as tamoxifen in the breast. Microdialysis was used for in situ sampling of extracellular proteins in normal breast tissue of women before and after six weeks of tamoxifen treatment or before and after addition of 25 g/day of ground flaxseed to the diet or in control women. We show significant correlations between estradiol and levels of VEGF, angiogenin, and endostatin in vivo, which was verified in ex vivo breast tissue culture. Moreover, tamoxifen decreased the levels of VEGF and angiogenin in the breast whereas endostatin increased significantly. Flaxseed did not alter VEGF or angiogenin levels but similar to tamoxifen the levels of endostatin increased significantly. We conclude that one of the mechanisms of tamoxifen in normal breast tissue include tipping of the angiogenic balance into an anti-angiogenic state and that flaxseed has limited effects on the pro-angiogenic factors whereas the anti-angiogenic endostatin may be modified by diet. Further studies of diet modifications for breast cancer prevention are warranted.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 4%
Poland 1 4%
United States 1 4%
Korea, Republic of 1 4%
Sweden 1 4%
Unknown 22 81%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 22%
Student > Ph. D. Student 6 22%
Other 4 15%
Researcher 4 15%
Professor 3 11%
Other 4 15%
Readers by discipline Count As %
Medicine and Dentistry 10 37%
Agricultural and Biological Sciences 8 30%
Chemistry 2 7%
Engineering 2 7%
Unspecified 1 4%
Other 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2017.
All research outputs
#7,017,539
of 9,207,038 outputs
Outputs from PLoS ONE
#89,800
of 122,460 outputs
Outputs of similar age
#63,325
of 86,002 outputs
Outputs of similar age from PLoS ONE
#1,532
of 1,935 outputs
Altmetric has tracked 9,207,038 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
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