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Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

Overview of attention for article published in Cancer Cell, May 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
11 tweeters
patent
3 patents

Citations

dimensions_citation
80 Dimensions

Readers on

mendeley
118 Mendeley
citeulike
2 CiteULike
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Title
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo
Published in
Cancer Cell, May 2015
DOI 10.1016/j.ccell.2015.04.008
Pubmed ID
Authors

Cara Lunn Shirai, James N. Ley, Brian S. White, Sanghyun Kim, Justin Tibbitts, Jin Shao, Matthew Ndonwi, Brian Wadugu, Eric J. Duncavage, Theresa Okeyo-Owuor, Tuoen Liu, Malachi Griffith, Sean McGrath, Vincent Magrini, Robert S. Fulton, Catrina Fronick, Michelle O’Laughlin, Timothy A. Graubert, Matthew J. Walter

Abstract

Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in ∼11% of patients with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is unclear how these mutations contribute to disease. We examined in vivo hematopoietic consequences of the most common U2AF1 mutation using a doxycycline-inducible transgenic mouse model. Mice expressing mutant U2AF1(S34F) display altered hematopoiesis and changes in pre-mRNA splicing in hematopoietic progenitor cells by whole transcriptome analysis (RNA-seq). Integration with human RNA-seq datasets determined that common mutant U2AF1-induced splicing alterations are enriched in RNA processing genes, ribosomal genes, and recurrently mutated MDS and acute myeloid leukemia-associated genes. These findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
United States 2 2%
Japan 1 <1%
Austria 1 <1%
Canada 1 <1%
Unknown 111 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 34%
Researcher 31 26%
Student > Master 10 8%
Unspecified 8 7%
Professor 7 6%
Other 22 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 44 37%
Biochemistry, Genetics and Molecular Biology 34 29%
Medicine and Dentistry 24 20%
Unspecified 9 8%
Computer Science 2 2%
Other 5 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2018.
All research outputs
#1,752,990
of 11,973,628 outputs
Outputs from Cancer Cell
#916
of 2,077 outputs
Outputs of similar age
#41,859
of 222,273 outputs
Outputs of similar age from Cancer Cell
#17
of 32 outputs
Altmetric has tracked 11,973,628 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,077 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.