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Bone Marrow-Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy

Overview of attention for article published in Stem Cells, June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
patent
3 patents
facebook
1 Facebook page

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
49 Mendeley
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Title
Bone Marrow-Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy
Published in
Stem Cells, June 2015
DOI 10.1002/stem.2050
Pubmed ID
Authors

Birgitta M. Gleeson, Kenneth Martin, Mohammed T. Ali, Arun H. S. Kumar, M. Gopala-Krishnan Pillai, Sujith P. G. Kumar, John F. O'Sullivan, Derek Whelan, Alessia Stocca, Wisam Khider, Frank P. Barry, Timothy O'Brien, Noel M. Caplice

Abstract

Mesenchymal stem cells (MSCs) are currently under investigation as tools to preserve cardiac structure and function following acute myocardial infarction (AMI). However, concerns have emerged regarding safety of acute intracoronary (IC) MSC delivery. This study aimed to characterize innate prothrombotic activity of MSC and identify means of its mitigation towards safe and efficacious therapeutic IC MSC delivery post AMI. Expression of the initiator of the coagulation cascade tissue factor (TF) on MSC was detected and quantified by immunofluorescence, FACS and immunoblotting. MSC-derived TF antigen was catalytically active and capable of supporting thrombin generation in vitro. Addition of MSCs to whole citrated blood enhanced platelet thrombus deposition on collagen at arterial shear, an effect abolished by heparin co-administration. In a porcine AMI model, intracoronary infusion of 25x10(6) MSC during reperfusion was associated with a decrease in coronary flow reserve but not when coadministered with an anti-thrombin agent (heparin). Heparin reduced MSC-associated thrombosis incorporating platelets and VWF within the microvasculature. Heparin-assisted therapeutic MSC delivery also reduced apoptosis in the infarct border zone at 24 hours, significantly improved infarct size, left ventricular ejection fraction, LV volumes, wall motion and attenuated histologic evidence of scar formation at six weeks post AMI. Heparin alone or heparin-assisted fibroblast control cell delivery had no such effect. Procoagulant TF activity of therapeutic MSCs is associated with reductions in myocardial perfusion when delivered IC may be successfully managed by heparin co-administration. This study highlights an important mechanistic insight into safety concerns associated with therapeutic IC MSC delivery for AMI. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 47 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 22%
Student > Ph. D. Student 10 20%
Student > Master 7 14%
Student > Doctoral Student 4 8%
Other 4 8%
Other 7 14%
Unknown 6 12%
Readers by discipline Count As %
Medicine and Dentistry 17 35%
Agricultural and Biological Sciences 7 14%
Biochemistry, Genetics and Molecular Biology 7 14%
Engineering 3 6%
Neuroscience 2 4%
Other 5 10%
Unknown 8 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2019.
All research outputs
#1,586,641
of 15,051,638 outputs
Outputs from Stem Cells
#409
of 3,472 outputs
Outputs of similar age
#30,132
of 232,020 outputs
Outputs of similar age from Stem Cells
#18
of 111 outputs
Altmetric has tracked 15,051,638 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,472 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.