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Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool

Overview of attention for article published in BMC Genomic Data, May 2015
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  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

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8 X users

Citations

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105 Dimensions

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83 Mendeley
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Title
Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool
Published in
BMC Genomic Data, May 2015
DOI 10.1186/s12863-015-0211-2
Pubmed ID
Authors

Zahra N. Sohani, David Meyre, Russell J. de Souza, Philip G. Joseph, Mandark Gandhi, Brittany B. Dennis, Geoff Norman, Sonia S. Anand

Abstract

Advances in genomics technology have led to a dramatic increase in the number of published genetic association studies. Systematic reviews and meta-analyses are a common method of synthesizing findings and providing reliable estimates of the effect of a genetic variant on a trait of interest. However, summary estimates are subject to bias due to the varying methodological quality of individual studies. We embarked on an effort to develop and evaluate a tool that assesses the quality of published genetic association studies. Performance characteristics (i.e. validity, reliability, and item discrimination) were evaluated using a sample of thirty studies randomly selected from a previously conducted systematic review. The tool demonstrates excellent psychometric properties and generates a quality score for each study with corresponding ratings of 'low', 'moderate', or 'high' quality. We applied our tool to a published systematic review to exclude studies of low quality, and found a decrease in heterogeneity and an increase in precision of summary estimates. This tool can be used in systematic reviews to inform the selection of studies for inclusion, to conduct sensitivity analyses, and to perform meta-regressions.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 17%
Student > Ph. D. Student 13 16%
Student > Bachelor 11 13%
Researcher 8 10%
Student > Postgraduate 4 5%
Other 13 16%
Unknown 20 24%
Readers by discipline Count As %
Medicine and Dentistry 15 18%
Biochemistry, Genetics and Molecular Biology 15 18%
Agricultural and Biological Sciences 7 8%
Neuroscience 4 5%
Nursing and Health Professions 2 2%
Other 13 16%
Unknown 27 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2018.
All research outputs
#7,355,005
of 25,371,288 outputs
Outputs from BMC Genomic Data
#252
of 1,203 outputs
Outputs of similar age
#81,687
of 279,368 outputs
Outputs of similar age from BMC Genomic Data
#9
of 33 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,203 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,368 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.