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Cognitive Enhancement

Overview of attention for book
Attention for Chapter 13: Pharmacological Disruption of Maladaptive Memory
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35 Mendeley
1 CiteULike
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Chapter title
Pharmacological Disruption of Maladaptive Memory
Chapter number 13
Book title
Cognitive Enhancement
Published in
Handbook of experimental pharmacology, January 2015
DOI 10.1007/978-3-319-16522-6_13
Pubmed ID
Book ISBNs
978-3-31-916521-9, 978-3-31-916522-6

Jane R. Taylor, Mary M. Torregrossa


Many psychiatric disorders are characterized by intrusive, distracting, and disturbing memories that either perpetuate the illness or hinder successful treatment. For example, posttraumatic stress disorder (PTSD) involves such strong reemergence of memories associated with a traumatic event that the individual feels like the event is happening again. Furthermore, drug addiction is characterized by compulsive use and repeated relapse that is often driven by internal memories of drug use and/or by exposure to external stimuli that were associated with drug use. Therefore, identifying pharmacological methods to weaken the strength of maladaptive memories is a major goal of research efforts aimed at finding new treatments for these disorders. The primary mechanism by which memories could be pharmacologically disrupted or altered is through manipulation of memory reconsolidation. Reconsolidation occurs when an established memory is remembered or reactivated, reentering a labile state before again being consolidated into long-term memory storage. Memories are subject to disruption during this labile state. In this chapter we will discuss the preclinical and clinical studies identifying potential pharmacological methods for disrupting the integrity of maladaptive memory to treat mental illness.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 7 20%
Student > Ph. D. Student 6 17%
Student > Master 5 14%
Student > Bachelor 5 14%
Researcher 3 9%
Other 5 14%
Unknown 4 11%
Readers by discipline Count As %
Psychology 13 37%
Medicine and Dentistry 6 17%
Agricultural and Biological Sciences 5 14%
Neuroscience 3 9%
Social Sciences 1 3%
Other 0 0%
Unknown 7 20%