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Cognitive Enhancement

Overview of attention for book
Attention for Chapter 4: Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers.
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1 tweeter
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1 Redditor

Citations

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71 Mendeley
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Chapter title
Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers.
Chapter number 4
Book title
Cognitive Enhancement
Published in
Handbook of experimental pharmacology, January 2015
DOI 10.1007/978-3-319-16522-6_4
Pubmed ID
Book ISBNs
978-3-31-916521-9, 978-3-31-916522-6
Authors

Costa, Veronica, Lugert, Sebastian, Jagasia, Ravi, Veronica Costa, Sebastian Lugert, Ravi Jagasia

Abstract

Adult hippocampal neurogenesis is a remarkable form of brain structural plasticity by which new functional neurons are generated from adult neural stem cells/precursors. Although the precise role of this process remains elusive, adult hippocampal neurogenesis is important for learning and memory and it is affected in disease conditions associated with cognitive impairment, depression, and anxiety. Immature neurons in the adult brain exhibit an enhanced structural and synaptic plasticity during their maturation representing a unique population of neurons to mediate specific hippocampal function. Compelling preclinical evidence suggests that hippocampal neurogenesis is modulated by a broad range of physiological stimuli which are relevant in cognitive and emotional states. Moreover, multiple pharmacological interventions targeting cognition modulate adult hippocampal neurogenesis. In addition, recent genetic approaches have shown that promoting neurogenesis can positively modulate cognition associated with both physiology and disease. Thus the discovery of signaling pathways that enhance adult neurogenesis may lead to therapeutic strategies for improving memory loss due to aging or disease. This chapter endeavors to review the literature in the field, with particular focus on (1) the role of hippocampal neurogenesis in cognition in physiology and disease; (2) extrinsic and intrinsic signals that modulate hippocampal neurogenesis with a focus on pharmacological targets; and (3) efforts toward novel strategies pharmacologically targeting neurogenesis and identification of biomarkers of human neurogenesis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 1%
United States 1 1%
Unknown 69 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 17 24%
Student > Master 10 14%
Student > Ph. D. Student 9 13%
Researcher 8 11%
Student > Doctoral Student 5 7%
Other 8 11%
Unknown 14 20%
Readers by discipline Count As %
Neuroscience 15 21%
Agricultural and Biological Sciences 12 17%
Medicine and Dentistry 11 15%
Psychology 7 10%
Biochemistry, Genetics and Molecular Biology 4 6%
Other 6 8%
Unknown 16 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2017.
All research outputs
#13,848,694
of 17,358,590 outputs
Outputs from Handbook of experimental pharmacology
#371
of 524 outputs
Outputs of similar age
#168,261
of 240,319 outputs
Outputs of similar age from Handbook of experimental pharmacology
#4
of 8 outputs
Altmetric has tracked 17,358,590 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 524 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,319 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.