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Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for diagnosing tegumentary leishmaniasis in regions of Leishmania (Viannia) predominance

Overview of attention for article published in Brazilian Journal of Infectious Diseases, May 2015
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Title
Field validation of a Leishmania (Leishmania) mexicana exo-antigens ELISA for diagnosing tegumentary leishmaniasis in regions of Leishmania (Viannia) predominance
Published in
Brazilian Journal of Infectious Diseases, May 2015
DOI 10.1016/j.bjid.2015.03.010
Pubmed ID
Authors

Killarney Ataide Soares, Ada Amália Ayala Urdapilleta, Gilcilene Maria dos Santos, Andréa Lisboa Carneiro, Ciro Martins Gomes, Ana Maria Roselino, Raimunda Nonata Ribeiro Sampaio

Abstract

Several tests are performed to obtain better accuracy when diagnosing American tegumentary leishmaniasis (ATL). It is believed that antigens released via secretion, excretion and metabolism are more specific than are antigens released by the lysis of Leishmania parasites. Such antigens are known as exo-antigens (exo-Ag) and are formed from products released by cultured parasites in a way that is similar to that in which they cause infections in hosts. We attempted to validate a Leishmania mexicana ELISA exo-Ag for ATL diagnosis in Midwestern Brazil. A total of 281 patients were included in the study. We analysed pre-treatment blood from 98 ATL patients; out of those, 85.7% and 14.3% had cutaneous and mucosal forms, respectively. The exo-Ag accuracy was 83.99% (95% CI=79.24-87.81) with a sensitivity value of 90.82% (95% CI=83.46-95.09) and an overall specificity value of 80.33% (95% CI=73.97-85.44). The positive predictive value and negative predictive value were 71.20% (95% CI=62.72-78.41) and 94.23% (95% CI=89.40-96.94), respectively. Among healthy controls, exo-Ag had a specificity of 91.25% (95% CI=83.02-95.70); additionally, the test had specificity rates of 66.67% (95% CI=46.71-82.03) in Chagas disease patients, 60.61% (95% CI=43.68-75.32) in patients with rheumatic diseases, 76.92% (95% CI=49.74-91.82) in pemphigus foliaceus patients, 87.50% (95% CI=52.91-97.76) in leprosy patients, 87.50% (95% CI=63.98-96.50) in VRDL-positive patients, and 77.78 (95% CI=45.26-93.68) in deep mycosis patients. Based on the indicators of validity, we conclude that the results obtained in this study enable the recommendation of the exo-Ag ELISA for ATL diagnosis once it presented a reasonable accuracy compared to classical methods. Cost evaluations are necessary to completely define the role of this technique in large scale.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 20%
Researcher 7 13%
Student > Bachelor 7 13%
Unspecified 3 6%
Student > Postgraduate 3 6%
Other 13 24%
Unknown 10 19%
Readers by discipline Count As %
Medicine and Dentistry 13 24%
Agricultural and Biological Sciences 6 11%
Veterinary Science and Veterinary Medicine 4 7%
Immunology and Microbiology 4 7%
Unspecified 3 6%
Other 11 20%
Unknown 13 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2016.
All research outputs
#8,405,300
of 13,418,168 outputs
Outputs from Brazilian Journal of Infectious Diseases
#154
of 347 outputs
Outputs of similar age
#124,180
of 233,857 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#4
of 9 outputs
Altmetric has tracked 13,418,168 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 347 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,857 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.