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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differentiation of malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine positron emission tomography
|
|---|---|
| Published in |
EJNMMI Research, April 2015
|
| DOI | 10.1186/s13550-015-0109-z |
| Pubmed ID | |
| Authors |
Aiko Yamaguchi, Hirofumi Hanaoka, Yutaka Fujisawa, Songji Zhao, Kazutomo Suzue, Akihiro Morita, Hideyuki Tominaga, Tetsuya Higuchi, Hajime Hisaeda, Yoshito Tsushima, Yuji Kuge, Yasuhiko Iida |
| Abstract |
Previous clinical studies have revealed the potential of [(18)F]-fluoro-L-α-methyltyrosine ((18)F-FAMT) for the differential diagnosis of malignant tumours from sarcoidosis. However, one concern regarding the differential diagnosis with (18)F-FAMT is the possibility of false negatives given the small absolute uptake of (18)F-FAMT that has been observed in some malignant tumours. The aim of this study was to evaluate a usefulness of dynamic (18)F-FAMT positron emission tomography (PET) for differentiating malignant tumours from granulomas. Rats bearing both granulomas (Mycobacterium bovis bacillus Calmette-Guérin (BCG)-induced) and tumours (C6 glioma cell-induced) underwent dynamic 2-deoxy-2-[(18)F]-fluoro-D-glucose ((18)F-FDG) PET and (18)F-FAMT PET for 120 min on consecutive days. Time-activity curves, static images, mean standardized uptake values (SUVs) and the SUV ratios (SUVRs; calculated by dividing SUV at each time point by that of 2 min after injection) were assessed. In tumours, (18)F-FAMT showed a shoulder peak immediately after the initial distribution followed by gradual clearance compared with granulomas. Although the mean SUV in the tumours (1.00 ± 0.10) was significantly higher than that in the granulomas (0.88 ± 0.12), a large overlap was observed. In contrast, the SUVR was markedly higher in tumours than in granulomas (50 min/2 min, 0.72 ± 0.06 and 0.56 ± 0.05, respectively) with no overlap. The dynamic patterns, SUVR, and mean SUV of (18)F-FDG in the granulomas were comparable to those in the tumours. Dynamic (18)F-FAMT and SUVR analysis might compensate for the current limitations and help in improving the diagnostic accuracy of (18)F-FAMT. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 32% |
| Researcher | 3 | 14% |
| Student > Bachelor | 3 | 14% |
| Professor > Associate Professor | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 1 | 5% |
| Unknown | 4 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 55% |
| Nursing and Health Professions | 1 | 5% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Psychology | 1 | 5% |
| Chemistry | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 6 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2015.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from EJNMMI Research
#385
of 556 outputs
Outputs of similar age
#222,415
of 263,955 outputs
Outputs of similar age from EJNMMI Research
#16
of 17 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 556 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.