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S6 kinase signaling: tamoxifen response and prognostic indication in two breast cancer cohorts

Overview of attention for article published in Endocrine-Related Cancer, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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4 tweeters

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11 Mendeley
Title
S6 kinase signaling: tamoxifen response and prognostic indication in two breast cancer cohorts
Published in
Endocrine-Related Cancer, June 2015
DOI 10.1530/erc-14-0513
Pubmed ID
Authors

Bostner, Josefine, Karlsson, Elin, Eding, Cecilia Bivik, Perez-Tenorio, Gizeh, Franzén, Hanna, Konstantinell, Aelita, Fornander, Tommy, Nordenskjöld, Bo, Stål, Olle, Josefine Bostner, Elin Karlsson, Cecilia Bivik Eding, Gizeh Perez-Tenorio, Hanna Franzén, Aelita Konstantinell, Tommy Fornander, Bo Nordenskjöld, Olle Stål

Abstract

Detection of signals in the mammalian target of rapamycin (mTOR) and the estrogen receptor (ER) pathways may be a future clinical tool for the prediction of adjuvant treatment response in primary breast cancer. Using immunohistological staining, we investigated the value of the mTOR targets p70-S6 kinase (S6K) 1 and 2 as biomarkers for tamoxifen benefit in two independent clinical trials comparing adjuvant tamoxifen with no tamoxifen or 5 years versus 2 years of tamoxifen treatment. In addition, the prognostic value of the S6Ks was evaluated. We found that S6K1 correlated with proliferation, HER2 status, and cytoplasmic AKT activity, whereas high protein expression levels of S6K2 and phosphorylated (p) S6K were more common in ER-positive, and low-proliferative tumors with pAKT-s473 localized to the nucelus. Nuclear accumulation of S6K1 was indicative of a reduced tamoxifen effect (hazard ratio (HR): 1.07, 95% CI: 0.53-2.81, P=0.84), compared with a significant benefit from tamoxifen treatment in patients without tumor S6K1 nuclear accumulation (HR: 0.42, 95% CI: 0.29-0.62, P<0.00001). Also S6K1 and S6K2 activation, indicated by pS6K-t389 expression, was associated with low benefit from tamoxifen (HR: 0.97, 95% CI: 0.50-1.87, P=0.92). In addition, high protein expression of S6K1, independent of localization, predicted worse prognosis in a multivariate analysis, P=0.00041 (cytoplasm), P=0.016 (nucleus). In conclusion, the mTOR-activated kinases S6K1 and S6K2 interfere with proliferation and response to tamoxifen. Monitoring their activity and intracellular localization may provide biomarkers for breast cancer treatment, allowing the identification of a group of patients less likely to benefit from tamoxifen and thus in need of an alternative or additional targeted treatment.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 36%
Student > Master 2 18%
Other 1 9%
Student > Postgraduate 1 9%
Student > Ph. D. Student 1 9%
Other 2 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 36%
Medicine and Dentistry 4 36%
Biochemistry, Genetics and Molecular Biology 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2016.
All research outputs
#5,872,382
of 11,433,395 outputs
Outputs from Endocrine-Related Cancer
#491
of 945 outputs
Outputs of similar age
#83,883
of 225,710 outputs
Outputs of similar age from Endocrine-Related Cancer
#6
of 23 outputs
Altmetric has tracked 11,433,395 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 945 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,710 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.