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Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species

Overview of attention for article published in Cell & Bioscience, January 2015
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Title
Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species
Published in
Cell & Bioscience, January 2015
DOI 10.1186/2045-3701-5-4
Pubmed ID
Authors

Haiqing Wang, Ting Liu, Lu Li, Qin Wang, Chunrong Yu, Xin Liu, Wenhua Li

Abstract

Autophagy is an evolutionarily conserved cellular process that involves the lysosomal degradation of proteins and organelles and the recycling of cellular components to ensure cellular survival under external or internal stress. Numerous data has indicated that autophagy can be successfully targeted for the treatment of multiple cancers. We have previously demonstrated that tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the broadly used Chinese medicinal herb Stephaniae tetrandrae, exhibits potent antitumor effects when used either alone or in combination with other drugs. In the present study, we showed that tetrandrine is a broad-spectrum potent autophagy agonist. Although low-dose tetrandrine treatment does not affect cell viability, it can potently induce autophagy in a variety of cell lines, including cancerous cells and nontumorigenic cells. The autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ), effectively blocked tetrandrine-induced autophagy. Moreover, tetrandrine significantly triggered the induction of mitophagy. The underlying mechanisms are associated with the tetrandrine-induced production of intracellular reactive oxygen species (ROS), which plays a critical role in tetrandrine-induced autophagy. Here, we report that tetrandrine is a potent cell autophagy agonist and may have a wide range of applications in the fields of antitumor therapy and basic scientific research.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Student > Master 3 19%
Student > Doctoral Student 2 13%
Student > Bachelor 2 13%
Student > Ph. D. Student 1 6%
Other 1 6%
Unknown 3 19%
Readers by discipline Count As %
Medicine and Dentistry 6 38%
Agricultural and Biological Sciences 2 13%
Biochemistry, Genetics and Molecular Biology 2 13%
Chemistry 1 6%
Unknown 5 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2015.
All research outputs
#4,241,407
of 5,099,132 outputs
Outputs from Cell & Bioscience
#121
of 141 outputs
Outputs of similar age
#140,897
of 170,693 outputs
Outputs of similar age from Cell & Bioscience
#7
of 7 outputs
Altmetric has tracked 5,099,132 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 141 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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