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BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing

Overview of attention for article published in Oncologist, May 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (84th percentile)

Mentioned by

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15 tweeters
facebook
2 Facebook pages

Citations

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7 Dimensions

Readers on

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25 Mendeley
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Title
BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing
Published in
Oncologist, May 2015
DOI 10.1634/theoncologist.2014-0425
Pubmed ID
Authors

Zahi I. Mitri, Michelle Jackson, Carolyn Garby, Juhee Song, Sharon H. Giordano, Gabriel N. Hortobágyi, Claire N. Singletary, S. Shahrukh Hashmi, Banu K. Arun, Jennifer K. Litton

Abstract

BRCAPRO is a risk assessment model to estimate the risk of carrying a BRCA mutation. BRCA mutation carriers are at higher risk of developing breast, ovarian, pancreatic, and prostate cancer. BRCAPRO was developed for women and found to be superior to other risk assessment models. The present study evaluated the validity of BRCAPRO at predicting the risk of male patients carrying a BRCA mutation. A total of 146 men who presented for genetic counseling and testing from February1997 to September 2011, and their test results were included in the present study. BRCAPRO risk assessment for all patients was calculated using the BRCAPRO clinical CancerGene assessment software. The mean age at presentation was 57 years. Of the 146 patients, 48 had breast cancer, 18 had pancreatic cancer, 39 had prostate cancer, 27 had other primary cancers, and 37 had no cancer. Fifty patients (34%) tested positive for a BRCA mutation (22 BRCA1, 27 BRCA2, and 1 BRCA1 and BRCA2). The mean BRCAPRO score for all patients was 24.96%. The BRCAPRO score was significantly higher for patients who tested positive for a BRCA mutation (46.19% vs. 13.9%, p < .01). The area under the receiver operating characteristics curve was 0.83 for all patients for the BRCAPRO score to predict the risk of carrying a BRCA mutation. At a cutoff point of 30.02%, the sensitivity, specificity, positive predictive value, and negative predictive value were 0.74, 0.81, 0.67, and 0.86, respectively. BRCAPRO appears to be a valid risk assessment tool for determining the risk of carrying a BRCA mutation in men.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 20%
Student > Doctoral Student 5 20%
Student > Master 3 12%
Student > Bachelor 2 8%
Professor > Associate Professor 2 8%
Other 5 20%
Unknown 3 12%
Readers by discipline Count As %
Medicine and Dentistry 15 60%
Biochemistry, Genetics and Molecular Biology 4 16%
Social Sciences 2 8%
Nursing and Health Professions 1 4%
Unknown 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2015.
All research outputs
#2,273,082
of 15,542,562 outputs
Outputs from Oncologist
#496
of 2,705 outputs
Outputs of similar age
#39,197
of 235,687 outputs
Outputs of similar age from Oncologist
#9
of 59 outputs
Altmetric has tracked 15,542,562 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,705 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,687 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.