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Bridging the age spectrum of neurodegenerative storage diseases

Overview of attention for article published in Best Practice & Research Clinical Endocrinology & Metabolism, September 2014
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Title
Bridging the age spectrum of neurodegenerative storage diseases
Published in
Best Practice & Research Clinical Endocrinology & Metabolism, September 2014
DOI 10.1016/j.beem.2014.08.009
Pubmed ID
Authors

Barry Boland, Frances M. Platt

Abstract

For over a century, researchers have observed similar neurodegenerative hallmarks in brains of people affected by rare early-onset lysosomal storage diseases and late-onset neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Increasing evidence suggests these apparently disparate diseases share a common underlying feature, namely, a dysfunctional clearance of cellular cargo through the secretory-endosomal-autophagic-lysosomal-exocytic (SEALE) network. By providing examples of rare and common neurodegenerative diseases known to have pathologically altered cargo flux through the SEALE network, we explore the unifying hypothesis that impaired catabolism or exocytosis of SEALE cargo, places a burden of stress on neurons that initiates pathogenesis. We also describe how a growing understanding of genetic, epigenetic and age-related modifications of the SEALE network, has inspired a number of novel disease-modifying therapeutic approaches aimed at alleviating SEALE storage and providing therapeutic benefit to people affected by these devastating diseases across the age spectrum.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Russia 1 1%
Unknown 72 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 23%
Researcher 17 23%
Student > Bachelor 10 14%
Student > Master 9 12%
Other 6 8%
Other 13 18%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 27%
Biochemistry, Genetics and Molecular Biology 17 23%
Neuroscience 12 16%
Medicine and Dentistry 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Other 11 15%
Unknown 3 4%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Best Practice & Research Clinical Endocrinology & Metabolism
#608
of 798 outputs
Outputs of similar age
#148,727
of 248,664 outputs
Outputs of similar age from Best Practice & Research Clinical Endocrinology & Metabolism
#12
of 14 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 798 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,664 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.