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Bridging the age spectrum of neurodegenerative storage diseases

Overview of attention for article published in Best Practice & Research Clinical Endocrinology & Metabolism, March 2015
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Mentioned by

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4 tweeters

Citations

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17 Dimensions

Readers on

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67 Mendeley
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Title
Bridging the age spectrum of neurodegenerative storage diseases
Published in
Best Practice & Research Clinical Endocrinology & Metabolism, March 2015
DOI 10.1016/j.beem.2014.08.009
Pubmed ID
Authors

Barry Boland, Frances M. Platt

Abstract

For over a century, researchers have observed similar neurodegenerative hallmarks in brains of people affected by rare early-onset lysosomal storage diseases and late-onset neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Increasing evidence suggests these apparently disparate diseases share a common underlying feature, namely, a dysfunctional clearance of cellular cargo through the secretory-endosomal-autophagic-lysosomal-exocytic (SEALE) network. By providing examples of rare and common neurodegenerative diseases known to have pathologically altered cargo flux through the SEALE network, we explore the unifying hypothesis that impaired catabolism or exocytosis of SEALE cargo, places a burden of stress on neurons that initiates pathogenesis. We also describe how a growing understanding of genetic, epigenetic and age-related modifications of the SEALE network, has inspired a number of novel disease-modifying therapeutic approaches aimed at alleviating SEALE storage and providing therapeutic benefit to people affected by these devastating diseases across the age spectrum.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Russia 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Researcher 17 25%
Student > Bachelor 9 13%
Student > Master 8 12%
Other 6 9%
Other 9 13%
Unknown 1 1%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 28%
Biochemistry, Genetics and Molecular Biology 15 22%
Neuroscience 12 18%
Medicine and Dentistry 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Other 10 15%
Unknown 2 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2016.
All research outputs
#7,514,930
of 12,016,495 outputs
Outputs from Best Practice & Research Clinical Endocrinology & Metabolism
#238
of 367 outputs
Outputs of similar age
#127,511
of 229,564 outputs
Outputs of similar age from Best Practice & Research Clinical Endocrinology & Metabolism
#4
of 4 outputs
Altmetric has tracked 12,016,495 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 367 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,564 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.