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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering
|
|---|---|
| Published in |
Nature Nanotechnology, April 2018
|
| DOI | 10.1038/s41565-018-0113-3 |
| Pubmed ID | |
| Authors |
Haogang Cai, James Muller, David Depoil, Viveka Mayya, Michael P. Sheetz, Michael L. Dustin, Shalom J. Wind |
| Abstract |
Elucidating the rules for receptor triggering in cell-cell and cell-matrix contacts requires precise control of ligand positioning in three dimensions. Here, we use the T cell receptor (TCR) as a model and subject T cells to different geometric arrangements of ligands, using a nanofabricated single-molecule array platform. This comprises monovalent TCR ligands anchored to lithographically patterned nanoparticle clusters surrounded by mobile adhesion molecules on a supported lipid bilayer. The TCR ligand could be co-planar with the supported lipid bilayer (2D), excluding the CD45 transmembrane tyrosine phosphatase, or elevated by 10 nm on solid nanopedestals (3D), allowing closer access of CD45 to engaged TCR. The two configurations resulted in different T cell responses, depending on the lateral spacing between the ligands. These results identify the important contributions of lateral and axial components of ligand positioning and create a more complete foundation for receptor engineering for immunotherapy. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 14% |
| United Kingdom | 3 | 9% |
| Switzerland | 2 | 6% |
| Germany | 1 | 3% |
| Iraq | 1 | 3% |
| Qatar | 1 | 3% |
| Japan | 1 | 3% |
| Greece | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Other | 7 | 20% |
| Unknown | 12 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 69% |
| Scientists | 9 | 26% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 188 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 37% |
| Researcher | 28 | 15% |
| Professor | 9 | 5% |
| Student > Bachelor | 9 | 5% |
| Student > Master | 9 | 5% |
| Other | 19 | 10% |
| Unknown | 45 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 37 | 20% |
| Engineering | 18 | 10% |
| Chemistry | 18 | 10% |
| Immunology and Microbiology | 17 | 9% |
| Agricultural and Biological Sciences | 16 | 9% |
| Other | 34 | 18% |
| Unknown | 48 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 102. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2018.
All research outputs
#384,149
of 24,083,187 outputs
Outputs from Nature Nanotechnology
#366
of 3,564 outputs
Outputs of similar age
#9,135
of 329,290 outputs
Outputs of similar age from Nature Nanotechnology
#11
of 82 outputs
Altmetric has tracked 24,083,187 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,564 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,290 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.