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Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering

Overview of attention for article published in Nature Nanotechnology, April 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
11 news outlets
blogs
2 blogs
twitter
39 tweeters

Citations

dimensions_citation
26 Dimensions

Readers on

mendeley
112 Mendeley
Title
Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering
Published in
Nature Nanotechnology, April 2018
DOI 10.1038/s41565-018-0113-3
Pubmed ID
Authors

Haogang Cai, James Muller, David Depoil, Viveka Mayya, Michael P. Sheetz, Michael L. Dustin, Shalom J. Wind

Abstract

Elucidating the rules for receptor triggering in cell-cell and cell-matrix contacts requires precise control of ligand positioning in three dimensions. Here, we use the T cell receptor (TCR) as a model and subject T cells to different geometric arrangements of ligands, using a nanofabricated single-molecule array platform. This comprises monovalent TCR ligands anchored to lithographically patterned nanoparticle clusters surrounded by mobile adhesion molecules on a supported lipid bilayer. The TCR ligand could be co-planar with the supported lipid bilayer (2D), excluding the CD45 transmembrane tyrosine phosphatase, or elevated by 10 nm on solid nanopedestals (3D), allowing closer access of CD45 to engaged TCR. The two configurations resulted in different T cell responses, depending on the lateral spacing between the ligands. These results identify the important contributions of lateral and axial components of ligand positioning and create a more complete foundation for receptor engineering for immunotherapy.

Twitter Demographics

The data shown below were collected from the profiles of 39 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 112 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 49 44%
Researcher 22 20%
Student > Master 8 7%
Student > Bachelor 6 5%
Professor 6 5%
Other 7 6%
Unknown 14 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 22%
Agricultural and Biological Sciences 16 14%
Engineering 12 11%
Chemistry 11 10%
Immunology and Microbiology 9 8%
Other 24 21%
Unknown 15 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 108. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2018.
All research outputs
#161,439
of 14,212,769 outputs
Outputs from Nature Nanotechnology
#204
of 2,695 outputs
Outputs of similar age
#6,853
of 274,151 outputs
Outputs of similar age from Nature Nanotechnology
#9
of 73 outputs
Altmetric has tracked 14,212,769 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,695 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,151 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.