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A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, April 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

policy
1 policy source
twitter
1 tweeter

Citations

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44 Dimensions

Readers on

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76 Mendeley
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Title
A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole
Published in
Memórias do Instituto Oswaldo Cruz, April 2015
DOI 10.1590/0074-02760140407
Pubmed ID
Authors

Bianca Zingales, Rafael Gomes Aquino Araujo, Margoth Moreno, Jaques Franco, Pedro Henrique Nascimento Aguiar, Solange Lessa Nunes, Marcelo Nunes Silva, Susan Ienne, Carlos Renato Machado, Adeilton Brandão

Abstract

Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassette (ABC) transporters are involved in a variety of translocation processes and some members have been implicated in drug resistance. Here we report the characterisation of the first T. cruzi ABCG transporter gene, named TcABCG1, which is over-expressed in parasite strains naturally resistant to BZ. Comparison of TcABCG1 gene sequence of two TcI BZ-resistant strains with CL Brener BZ-susceptible strain showed several single nucleotide polymorphisms, which determined 11 amino acid changes. CL Brener transfected with TcI transporter genes showed 40-47% increased resistance to BZ, whereas no statistical significant increment in drug resistance was observed when CL Brener was transfected with the homologous gene. Only in the parasites transfected with TcI genes there was 2-2.6-fold increased abundance of TcABCG1 transporter protein. The analysis in wild type strains also suggests that the level of TcABCG1 transporter is related to BZ natural resistance. The characteristics of untranslated regions of TcABCG1 genes of BZ-susceptible and resistant strains were investigated by computational tools.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 14%
Student > Doctoral Student 11 14%
Student > Bachelor 10 13%
Student > Ph. D. Student 8 11%
Student > Master 6 8%
Other 15 20%
Unknown 15 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 26%
Biochemistry, Genetics and Molecular Biology 17 22%
Medicine and Dentistry 6 8%
Chemistry 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Other 10 13%
Unknown 13 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2015.
All research outputs
#7,215,016
of 22,805,349 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#246
of 1,377 outputs
Outputs of similar age
#86,682
of 264,480 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#8
of 31 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,377 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,480 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.