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Evaluation of parasitological and molecular techniques for the diagnosis and assessment of cure of schistosomiasis mansoni in a low transmission area

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, April 2015
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Title
Evaluation of parasitological and molecular techniques for the diagnosis and assessment of cure of schistosomiasis mansoni in a low transmission area
Published in
Memórias do Instituto Oswaldo Cruz, April 2015
DOI 10.1590/0074-02760140375
Pubmed ID
Authors

Liliane Maria Vidal Siqueira, Luciana Inácia Gomes, Edward Oliveira, Eduardo Ribeiro de Oliveira, Áureo Almeida de Oliveira, Martin Johannes Enk, Nídia Figueiredo Carneiro, Ana Rabello, Paulo Marcos Zech Coelho

Abstract

This study evaluated parasitological and molecular techniques for the diagnosis and assessment of cure of schistosomiasis mansoni. A population-based study was performed in 201 inhabitants from a low transmission locality named Pedra Preta, municipality of Montes Claros, state of Minas Gerais, Brazil. Four stool samples were analysed using two techniques, the Kato-Katz® (KK) technique (18 slides) and the TF-Test®, to establish the infection rate. The positivity rate of 18 KK slides of four stool samples was 28.9% (58/201) and the combined parasitological techniques (KK+TF-Test®) produced a 35.8% positivity rate (72/201). Furthermore, a polymerase chain reaction (PCR)-ELISA assay produced a positivity rate of 23.4% (47/201) using the first sample. All 72 patients with positive parasitological exams were treated with a single dose of Praziquantel® and these patients were followed-up 30, 90 and 180 days after treatment to establish the cure rate. Cure rates obtained by the analysis of 12 KK slides were 100%, 100% and 98.4% at 30, 90 and 180 days after treatment, respectively. PCR-ELISA revealed cure rates of 98.5%, 95.5% and 96.5%, respectively. The diagnostic and assessment of cure for schistosomiasis may require an increased number of KK slides or a test with higher sensitivity, such as PCR-ELISA, in situations of very low parasite load, such as after therapeutic interventions.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 25%
Student > Bachelor 11 17%
Researcher 7 11%
Student > Doctoral Student 6 9%
Student > Postgraduate 5 8%
Other 9 14%
Unknown 11 17%
Readers by discipline Count As %
Medicine and Dentistry 15 23%
Agricultural and Biological Sciences 14 22%
Biochemistry, Genetics and Molecular Biology 9 14%
Immunology and Microbiology 4 6%
Nursing and Health Professions 3 5%
Other 8 12%
Unknown 12 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2015.
All research outputs
#11,127,490
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#767
of 862 outputs
Outputs of similar age
#192,160
of 232,439 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#7
of 7 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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