↓ Skip to main content

The expression profile of Aedes albopictus miRNAs is altered by dengue virus serotype-2 infection

Overview of attention for article published in Cell & Bioscience, April 2015
Altmetric Badge

Mentioned by

twitter
2 tweeters

Citations

dimensions_citation
48 Dimensions

Readers on

mendeley
39 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The expression profile of Aedes albopictus miRNAs is altered by dengue virus serotype-2 infection
Published in
Cell & Bioscience, April 2015
DOI 10.1186/s13578-015-0009-y
Pubmed ID
Authors

Yanxia Liu, Yanhe Zhou, Jinya Wu, Peiming Zheng, Yiji Li, Xiaoying Zheng, Santhosh Puthiyakunnon, Zhijian Tu, Xiao-Guang Chen

Abstract

Aedes albopictus is an important vector of Dengue virus (DENV) and it has quickly invaded the tropical and temperate environments worldwide. A few studies have shown that, microRNAs (miRNAs) regulate mosquito defense against pathogens. However, there is no systematic analysis of the impact of DENV infection on miRNA expression in Ae. albopictus. We conducted this study to investigate the miRNA expression of Ae. albopictus upon DENV-2 infection using Illumina RNA sequencing. A total of 103 known and 5 novel candidate miRNAs were identified in DENV-2 infected and non-infected adult female Ae. albopictus. Comparative analysis indicated that 52 miRNAs were significantly down-regulated and 18 were up-regulated significantly after infection. Furthermore, RT-qPCR validated the expression patterns of eleven of these differentially expressed miRNAs. Targets prediction and functional analysis of these regulated miRNAs suggested that miR-34-5p and miR-87 might be involved in the anti-pathogen and immune responses. This is the first systematic study on the impact of DENV infection on miRNA expression in Ae. albopictus. Complex changes in miRNA expression suggest a potential role of miRNAs in antiviral responses by regulating immune-related genes. This investigation provides information concerning DENV-induced miRNAs and offers clues for identifying potential candidates for vector based antiviral strategies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Student > Ph. D. Student 8 21%
Student > Bachelor 5 13%
Student > Master 4 10%
Other 2 5%
Other 8 21%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 28%
Biochemistry, Genetics and Molecular Biology 8 21%
Medicine and Dentistry 4 10%
Veterinary Science and Veterinary Medicine 3 8%
Immunology and Microbiology 3 8%
Other 6 15%
Unknown 4 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2015.
All research outputs
#3,539,052
of 5,042,185 outputs
Outputs from Cell & Bioscience
#91
of 137 outputs
Outputs of similar age
#120,619
of 168,802 outputs
Outputs of similar age from Cell & Bioscience
#6
of 7 outputs
Altmetric has tracked 5,042,185 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 137 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,802 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.