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Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers

Overview of attention for article published in Clinical Epigenetics, April 2015
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3 tweeters

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Title
Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers
Published in
Clinical Epigenetics, April 2015
DOI 10.1186/s13148-015-0082-4
Pubmed ID
Authors

Hellen Kuasne, Ilce Mara de Syllos Cólus, Ariane Fidelis Busso, Hector Hernandez-Vargas, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Cristovam Scapulatempo-Neto, Eliney Ferreira Faria, Ademar Lopes, Gustavo Cardoso Guimarães, Zdenko Herceg, Silvia Regina Rogatto

Abstract

Despite penile carcinoma (PeCa) being a relatively rare neoplasm, it remains an important public health issue for poor and developing countries. Contrary to most tumors, limited data are available for markers that are capable of assisting in diagnosis, prognosis, and treatment of PeCa. We aimed to identify molecular markers for PeCa by evaluating their epigenomic and transcriptome profiles and comparing them with surrounding non-malignant tissue (SNT) and normal glans (NG). Genome-wide methylation analysis revealed 171 hypermethylated probes in PeCa. Transcriptome profiling presented 2,883 underexpressed and 1,378 overexpressed genes. Integrative analysis revealed a panel of 54 genes with an inverse correlation between methylation and gene expression levels. Distinct methylome and transcriptome patterns were found for human papillomavirus (HPV)-positive (38.6%) and negative tumors. Interestingly, grade 3 tumors showed a distinct methylation profile when compared to grade 1. In addition, univariate analysis revealed that low BDNF methylation was associated with lymph node metastasis and shorter disease-free survival. CpG hypermethylation and gene underexpression were confirmed for a panel of genes, including TWIST1, RSOP2, SOX3, SOX17, PROM1, OTX2, HOXA3, and MEIS1. A unique methylome signature was found for PeCa compared to SNT, with aberrant DNA methylation appearing to modulate the expression of specific genes. This study describes new pathways with the potential to regulate penile carcinogenesis, including stem cell regulatory pathways and markers associated to a worse prognosis. These findings may be instrumental in the discovery and application of new genetic and epigenetic biomarkers in PeCa.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 5%
Canada 1 3%
Unknown 34 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 27%
Researcher 7 19%
Student > Doctoral Student 5 14%
Other 4 11%
Professor > Associate Professor 2 5%
Other 5 14%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 8 22%
Biochemistry, Genetics and Molecular Biology 8 22%
Agricultural and Biological Sciences 7 19%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Social Sciences 2 5%
Other 3 8%
Unknown 7 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2015.
All research outputs
#3,600,718
of 7,419,460 outputs
Outputs from Clinical Epigenetics
#290
of 365 outputs
Outputs of similar age
#106,548
of 213,797 outputs
Outputs of similar age from Clinical Epigenetics
#17
of 19 outputs
Altmetric has tracked 7,419,460 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 365 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.