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Anti-Amyloidogenic Properties of Some Phenolic Compounds.

Overview of attention for article published in Biomolecules, January 2015
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32 Mendeley
Title
Anti-Amyloidogenic Properties of Some Phenolic Compounds.
Published in
Biomolecules, January 2015
DOI 10.3390/biom5020505
Pubmed ID
Authors

Porzoor, Afsaneh, Alford, Benjamin, Hügel, Helmut M, Grando, Danilla, Caine, Joanne, Macreadie, Ian, Afsaneh Porzoor, Benjamin Alford, Helmut M. Hügel, Danilla Grando, Joanne Caine, Ian Macreadie

Abstract

A family of 21 polyphenolic compounds consisting of those found naturally in danshen and their analogues were synthesized and subsequently screened for their anti-amyloidogenic activity against the amyloid beta peptide (Aβ42) of Alzheimer's disease. After 24 h incubation with Aβ42, five compounds reduced thioflavin T (ThT) fluorescence, indicative of their anti-amyloidogenic propensity (p < 0.001). TEM and immunoblotting analysis also showed that selected compounds were capable of hindering fibril formation even after prolonged incubations. These compounds were also capable of rescuing the yeast cells from toxic changes induced by the chemically synthesized Aβ42. In a second assay, a Saccharomyces cerevisiae AHP1 deletant strain transformed with GFP fused to Aβ42 was treated with these compounds and analyzed by flow cytometry. There was a significant reduction in the green fluorescence intensity associated with 14 compounds. We interpret this result to mean that the compounds had an anti-amyloid-aggregation propensity in the yeast and GFP-Aβ42 was removed by proteolysis. The position and not the number of hydroxyl groups on the aromatic ring was found to be the most important determinant for the anti-amyloidogenic properties.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 22%
Student > Ph. D. Student 6 19%
Researcher 5 16%
Other 4 13%
Student > Bachelor 4 13%
Other 6 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 34%
Agricultural and Biological Sciences 8 25%
Unspecified 5 16%
Medicine and Dentistry 3 9%
Business, Management and Accounting 1 3%
Other 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2017.
All research outputs
#7,012,983
of 9,201,335 outputs
Outputs from Biomolecules
#170
of 251 outputs
Outputs of similar age
#158,072
of 222,711 outputs
Outputs of similar age from Biomolecules
#22
of 37 outputs
Altmetric has tracked 9,201,335 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 251 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,711 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.