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Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population

Overview of attention for article published in Arthritis Research & Therapy, March 2015
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Title
Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population
Published in
Arthritis Research & Therapy, March 2015
DOI 10.1186/s13075-015-0602-9
Pubmed ID
Authors

Yu-jun Sheng, Jian-hua Xu, Yong-gui Wu, Xian-bo Zuo, Jin-ping Gao, Yan Lin, Zheng-wei Zhu, Lei-lei Wen, Chao Yang, Lu Liu, Yu-yan Cheng, Yan Chang, Lu-lu Yang, Fu-sheng Zhou, Xian-fa Tang, Xiao-dong Zheng, Xian-yong Yin, Hua-yang Tang, Liang-dan Sun, Yong Cui, Sen Yang, Xue-jun Zhang

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Currently, numerous genetic loci of SLE have been confirmed. Here we try to further explore additional genes contributing to SLE susceptibility in this study. Forty nine single nucleotide polymorphisms (SNPs) with moderate-risk for SLE in previous study were genotyped in a large-scale replication study with a total of 3,522 cases and 8,252 controls using the Sequenom Massarray system. Association analyses were performed using logistic regression with gender or sample cohorts as a covariate through PLINK 1.07 software. This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P meta <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P meta = 1.08 × 10(-08); rs4916219, OR = 0.80, P meta = 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P meta = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P meta = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P meta = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P meta = 1.01 × 10(-09)). Further logistic regression analysis indicated that the genetic effects within TNFSF4 detected in this study are independent from our previously reported signals. This study increases the number of established susceptibility loci for SLE in Han Chinese population and highlights the contribution of multiple variants of modest effect. Although further studies will be required to identify the causal alleles within these loci, the findings make a significant step forward in our understanding of the genetic contribution to SLE in Chinese population.

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Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 5%
United States 1 5%
Unknown 17 89%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 32%
Researcher 2 11%
Student > Doctoral Student 2 11%
Student > Ph. D. Student 2 11%
Professor 1 5%
Other 4 21%
Unknown 2 11%
Readers by discipline Count As %
Medicine and Dentistry 4 21%
Biochemistry, Genetics and Molecular Biology 3 16%
Immunology and Microbiology 3 16%
Agricultural and Biological Sciences 2 11%
Computer Science 1 5%
Other 4 21%
Unknown 2 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2016.
All research outputs
#7,813,293
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#1,414
of 1,983 outputs
Outputs of similar age
#123,437
of 229,577 outputs
Outputs of similar age from Arthritis Research & Therapy
#47
of 65 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.