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Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance

Overview of attention for article published in Diabetology & Metabolic Syndrome, March 2015
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Title
Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
Published in
Diabetology & Metabolic Syndrome, March 2015
DOI 10.1186/s13098-015-0019-2
Pubmed ID
Authors

Xinmiao Xie, Ting Gao, Meili Yang, Peihong Chen, Hua Jin, Lili Yang, Xuemei Yu

Abstract

Betatrophin may increase islet β cell proliferation in insulin resistance and irisin may improve glucose tolerance in mice. To examine the relationship between betatrophin and irisin, we investigated it in middle-aged Chinese subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM). A total of 460 permanent residents of Fengxian District, aged 40-60 years and without T2DM, were enrolled. Anthropometric parameters, oral glucose tolerance test (OGTT) results, glycosylated haemoglobin levels, blood lipid levels, insulin sensitivity (homeostasis model assessment of insulin resistance, HOMA-IR), β cell function (homeostasis model assessment-β, HOMA-β), estimated glomerular filtration rate (eGFR) and body fat composition were determined. Matched for age, gender and body mass index (BMI, 18-28 kg/m2), newly diagnosed T2DM (n = 50, male/female = 23/27) and NGT (n = 50, male/female = 21/29) subjects were selected based on the results of an OGTT. Serum betatrophin and irisin levels were determined by enzyme linked immune sorbent assay (ELISA). Males had higher levels of betatrophin compared with females in both the NGT and T2DM groups. Compared with NGT subjects, the level of betatrophin in the T2DM group was higher, and males in the T2DM group had higher betatrophin levels than males in the NGT group, but there was no significant difference in betatrophin levels in females between the T2DM and NGT groups. Spearman's correlation analysis revealed that serum betatrophin levels in females with NGT were positively correlated with irisin and negatively correlated with FINS (fasting insulin) levels ( p < 0.05), but no correlation was found between betatrophin and irisin levels in males with NGT or in males or females with T2DM. In females with T2DM, circulating betatrophin levels were positively correlated with weight, BMI and hip circumference (p < 0.05) but negatively correlated with FPG (fasting plasma glucose) and HOMA-IR (p < 0.05). Gender differences in the relationship between betatrophin and irisin indicate that there might be cytokine-mediated crosstalk among the liver, adipose tissue and skeletal muscle.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iraq 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 28%
Student > Ph. D. Student 5 14%
Researcher 3 8%
Student > Bachelor 3 8%
Student > Postgraduate 2 6%
Other 5 14%
Unknown 8 22%
Readers by discipline Count As %
Medicine and Dentistry 13 36%
Nursing and Health Professions 3 8%
Sports and Recreations 3 8%
Social Sciences 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 3 8%
Unknown 10 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2015.
All research outputs
#4,165,307
of 4,982,174 outputs
Outputs from Diabetology & Metabolic Syndrome
#186
of 227 outputs
Outputs of similar age
#139,205
of 168,173 outputs
Outputs of similar age from Diabetology & Metabolic Syndrome
#14
of 15 outputs
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So far Altmetric has tracked 227 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.