Title |
Effects of early life trauma are dependent on genetic predisposition: a rat study
|
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Published in |
Behavioral and Brain Functions, May 2011
|
DOI | 10.1186/1744-9081-7-11 |
Pubmed ID | |
Authors |
Toni-Lee Sterley, Fleur M Howells, Vivienne A Russell |
Abstract |
Trauma experienced early in life increases the risk of developing a number of psychological and/or behavioural disorders. It is unclear, however, how genetic predisposition to a behavioural disorder, such as attention-deficit/hyperactivity disorder (ADHD), modifies the long-term effects of early life trauma. There is substantial evidence from family and twin studies for susceptibility to ADHD being inherited, implying a strong genetic component to the disorder. In the present study we used an inbred animal model of ADHD, the spontaneously hypertensive rat (SHR), to investigate the long-term consequences of early life trauma on emotional behaviour in individuals predisposed to developing ADHD-like behaviour. |
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