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Expression of meis and hoxa11 in dipnoan and teleost fins provides new insights into the evolution of vertebrate appendages

Overview of attention for article published in EvoDevo, April 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)

Mentioned by

twitter
7 tweeters

Readers on

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18 Mendeley
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Title
Expression of meis and hoxa11 in dipnoan and teleost fins provides new insights into the evolution of vertebrate appendages
Published in
EvoDevo, April 2018
DOI 10.1186/s13227-018-0099-9
Pubmed ID
Authors

Fernanda Langellotto, Maria Fiorentino, Elena De Felice, Luigi Caputi, Valeria Nittoli, Jean M. P. Joss, Paolo Sordino

Abstract

The concerted activity of Meis and Hoxa11 transcription factors is essential for the subdivision of tetrapod limbs into proximo-distal (PD) domains; however, little is know about the evolution of this patterning mechanism. Here, we aim to study the expression of meis and hoxa11 orthologues in the median and paired rayed fins of zebrafish and in the lobed fins of the Australian lungfish. First, a late phase of expression of meis1.1 and hoxa11b in zebrafish dorsal and anal fins relates with segmentation of endochondral elements in proximal and distal radials. Second, our zebrafish in situ hybridization results reveal spatial and temporal changes between pectoral and pelvic fins. Third, in situ analysis of meis1, meis3 and hoxa11 genes in Neoceratodus pectoral fins identifies decoupled domains of expression along the PD axis. Our data raise the possibility that the origin of stylopod and zeugopod lies much deeper in gnathostome evolution and that variation in meis and hoxa11 expression has played a substantial role in the transformation of appendage anatomy. Moreover, these observations provide evidence that the Meis/Hoxa11 profile considered a hallmark of stylopod/zeugopod patterning is present in Neoceratodus.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 39%
Researcher 4 22%
Student > Master 4 22%
Unknown 3 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 44%
Agricultural and Biological Sciences 4 22%
Environmental Science 1 6%
Earth and Planetary Sciences 1 6%
Unknown 4 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2018.
All research outputs
#6,702,326
of 12,920,212 outputs
Outputs from EvoDevo
#131
of 231 outputs
Outputs of similar age
#111,992
of 268,747 outputs
Outputs of similar age from EvoDevo
#1
of 1 outputs
Altmetric has tracked 12,920,212 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 231 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,747 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them