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HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung

Overview of attention for article published in AIDS Research and Therapy, October 2011
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  • High Attention Score compared to outputs of the same age and source (81st percentile)

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3 tweeters

Citations

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14 Dimensions

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15 Mendeley
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Title
HIV-1 transgene expression in rats induces differential expression of tumor necrosis factor alpha and zinc transporters in the liver and the lung
Published in
AIDS Research and Therapy, October 2011
DOI 10.1186/1742-6405-8-36
Pubmed ID
Authors

Pratibha C Joshi, Pratibha C Joshi, David M Guidot

Abstract

Highly effective antiviral treatment can suppress HIV-1 infection, but the chronic effects of HIV-1-related viral proteins, including gp120 and Tat, on organs such as the lungs can be damaging. HIV-1 transgenic rodent models are useful for studying the systemic effects of these proteins independently of viral infection. We have previously shown that HIV-1 transgene expression (and therefore, HIV-1-related protein expression) in rats decreases alveolar macrophage zinc levels and phagocytic capacity by unknown mechanisms. We hypothesized that HIV-1 transgene expression induces chronic inflammation and zinc sequestration within the liver and thereby decreases zinc bioavailability in the lung. We examined the expression of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNFα), the zinc storage protein, metallothionein (MT1), and the zinc exporter, ZNT1 in the livers and the lungs of wild type and HIV-1 transgenic rats ± dietary zinc supplementation. In addition, we measured zinc levels, the zinc importing protein ZIP1, and the phagocytic capacity in the alveolar macrophages.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 7%
Unknown 14 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 53%
Student > Master 3 20%
Professor 1 7%
Student > Bachelor 1 7%
Student > Doctoral Student 1 7%
Other 1 7%
Readers by discipline Count As %
Medicine and Dentistry 6 40%
Agricultural and Biological Sciences 5 33%
Biochemistry, Genetics and Molecular Biology 2 13%
Immunology and Microbiology 1 7%
Engineering 1 7%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2011.
All research outputs
#1,734,960
of 4,704,568 outputs
Outputs from AIDS Research and Therapy
#66
of 199 outputs
Outputs of similar age
#18,508
of 68,845 outputs
Outputs of similar age from AIDS Research and Therapy
#2
of 11 outputs
Altmetric has tracked 4,704,568 research outputs across all sources so far. This one has received more attention than most of these and is in the 62nd percentile.
So far Altmetric has tracked 199 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,845 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.