Title |
Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
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Published in |
Breast Cancer Research, July 2011
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DOI | 10.1186/bcr2916 |
Pubmed ID | |
Authors |
Volkmar Müller, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter A Fasching, Erich Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Julia Zeitz, Klaus Pantel, Tanja Fehm, the DETECT study group |
Abstract |
Circulating tumor cells (CTCs) reflect aggressive tumor behavior by hematogenous tumor cell dissemination. The tissue inhibitor of metalloproteinase 1 (TIMP-1) plays a role in tissue invasion and is also involved in angiogenesis, abrogation of apoptosis and in chemoresistance. Carbonic anhydrase IX (CAIX) is a metalloenzyme involved in cell adhesion, growth and survival of tumor cells. The aim of the study was to investigate whether serum concentrations of TIMP-1 and CAIX are associated with the detection of CTC in metastatic breast cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 24% |
Researcher | 10 | 20% |
Student > Master | 8 | 16% |
Student > Doctoral Student | 4 | 8% |
Student > Bachelor | 4 | 8% |
Other | 4 | 8% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 19 | 38% |
Agricultural and Biological Sciences | 10 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Chemistry | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Other | 1 | 2% |
Unknown | 11 | 22% |