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Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice

Overview of attention for article published in Biomarker Research, February 2018
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Title
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice
Published in
Biomarker Research, February 2018
DOI 10.1186/s40364-018-0120-4
Pubmed ID
Authors

Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock, Linda J. Bendall

Abstract

Sphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL). In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF. Mice lacking ARF and SphK2 had a significantly reduced incidence of ALL compared mice with wild type SphK2. These results show that the role of SphK2 in ALL development is not limited to BCR/ABL1 driven disease extending the potential use of inhibitors of this enzyme to ALL patients whose disease have driver mutations other than BCR/ABL1.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 14%
Professor > Associate Professor 1 14%
Researcher 1 14%
Lecturer 1 14%
Unknown 3 43%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 29%
Biochemistry, Genetics and Molecular Biology 1 14%
Unknown 4 57%