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Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia—A Systematic Review With Meta-analysis

Overview of attention for article published in Gastroenterology, August 2018
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

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5 tweeters
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3 Facebook pages

Citations

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19 Dimensions

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55 Mendeley
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Title
Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia—A Systematic Review With Meta-analysis
Published in
Gastroenterology, August 2018
DOI 10.1053/j.gastro.2018.04.016
Pubmed ID
Authors

Srihari Mahadev, Monika Laszkowska, Johan Sundström, Magnus Björkholm, Benjamin Lebwohl, Peter H.R. Green, Jonas F. Ludvigsson

Abstract

Anemia is common in patients with celiac disease and a frequent presentation. Guidelines recommend screening iron-deficient patients with anemia for celiac disease. However, the reported prevalence of celiac disease among patients with iron-deficiency anemia (IDA) varies. We performed a systematic review to determine the prevalence of biopsy-verified celiac disease in patients with IDA. We performed a systematic review of manuscripts published in PubMed Medline or EMBASE through July 2017 for the term celiac disease combined with anemia or iron-deficiency. We used fixed-effects inverse variance-weighted models to measure the pooled prevalence of celiac disease. Meta-regression was used to assess subgroup heterogeneity. We identified 18 studies comprising 2998 patients with IDA for inclusion in our analysis. Studies originated from the United Kingdom, United States, Italy, Turkey, Iran, and Israel. The crude unweighted prevalence of celiac disease was 4.8% (n=143). Using a weighted pooled analysis, we demonstrated a prevalence of biopsy-confirmed celiac disease 3.2% (95% CI, 2.6%-3.9%) in patients with IDA. However, heterogeneity was high (I2 = 67.7%). The prevalence of celiac disease was not significantly higher in studies with a mean participant age older or younger than years, nor in studies with a mixed-sex vs female-predominant (≥60%) population. On meta-regression, year of publication, the proportion of females, age at celiac disease testing, and the prevalence of in the general population were not associated with the prevalence of celiac disease in patients with IDA. In the 8 studies fulfilling all our quality criteria, the pooled prevalence of celiac disease was 5.5% (95% CI, 4.1%-6.9%). In a systematic review and meta-analysis, we found that approximately 1 in 31 patients with IDA have histologic evidence of celiac disease. This prevalence value justifies the practice of testing patients with IDA for celiac disease.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Other 7 13%
Student > Postgraduate 6 11%
Student > Bachelor 6 11%
Researcher 5 9%
Student > Ph. D. Student 5 9%
Other 13 24%
Unknown 13 24%
Readers by discipline Count As %
Medicine and Dentistry 23 42%
Nursing and Health Professions 5 9%
Biochemistry, Genetics and Molecular Biology 3 5%
Agricultural and Biological Sciences 2 4%
Engineering 2 4%
Other 7 13%
Unknown 13 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2018.
All research outputs
#4,140,949
of 15,813,915 outputs
Outputs from Gastroenterology
#3,364
of 9,704 outputs
Outputs of similar age
#88,922
of 279,128 outputs
Outputs of similar age from Gastroenterology
#85
of 187 outputs
Altmetric has tracked 15,813,915 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 9,704 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,128 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 187 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.