Title |
The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI
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Published in |
Journal of Hematology & Oncology, October 2011
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DOI | 10.1186/1756-8722-4-42 |
Pubmed ID | |
Authors |
Christina Halsey, Georgina Buck, Sue Richards, Faraneh Vargha-Khadem, Frank Hill, Brenda Gibson |
Abstract |
The MRC UKALLXI trial tested the efficacy of different central nervous system (CNS) directed therapies in childhood acute lymphoblastic leukaemia (ALL). To evaluate morbidity 555/1826 randomised children underwent prospective psychological evaluations. Full Scale, verbal and performance IQs were measured at 5 months, 3 years and 5 years. Scores were compared in; (1) all patients (n = 555) versus related controls (n = 311), (2) low-risk children (presenting white cell count (WCC) < 50 × 10(9)/l) randomised to intrathecal methotrexate (n = 197) versus intrathecal and high-dose intravenous methotrexate (HDM) (n = 202), and (3) high-risk children (WCC ≥ 50 × 10(9)/l, age ≥ 2 years) randomised to HDM (n = 79) versus cranial irradiation (n = 77). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 17% |
Student > Master | 10 | 17% |
Student > Bachelor | 7 | 12% |
Other | 5 | 8% |
Researcher | 5 | 8% |
Other | 12 | 20% |
Unknown | 10 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 41% |
Psychology | 9 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Neuroscience | 3 | 5% |
Agricultural and Biological Sciences | 2 | 3% |
Other | 6 | 10% |
Unknown | 9 | 15% |