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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers
|
|---|---|
| Published in |
Breast Cancer Research, May 2015
|
| DOI | 10.1186/s13058-015-0577-0 |
| Pubmed ID | |
| Authors |
Shandong Wu, Susan P Weinstein, Michael J DeLeo, Emily F Conant, Jinbo Chen, Susan M Domchek, Despina Kontos |
| Abstract |
We present a fully-automated method for deriving quantitative measures of background parenchymal enhancement (BPE) from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perform a preliminary evaluation of these measures to assess the effect of risk-reducing salpingo-oophorectomy (RRSO) in a cohort of BReast CAncer susceptibility gene 1/2 (BRCA1/2) mutation carriers. Breast DCE-MRI data from 50 BRCA1/2 carriers were retrospectively analyzed under the Health Insurance Portability and Accountability Act (HIPAA) and institutional review board approval. Both the absolute (| |) and relative ( %) measures of BPE and fibroglandular tissue (FGT) were computed from the MRI scans acquired before and after RRSO. These pre- and post-RRSO measures were compared using paired Student's t-test. The area under the curve (AUC) of the receiver operating characteristic (ROC) were used to evaluate the performance of relative changes in the BPE and FGT measures in predicting breast cancer developed among these women after the RRSO surgery. For the 44 women who did not develop breast cancer after RRSO, absolute volume of BPE and FGT has a significant decrease (p < 0.05) post-RRSO, while for the 6 women who developed breast cancer there are no significant changes in these measures. Higher values in all BPE and FGT measures are also observed post-RRSO for the women who developed breast cancer, compared to women who did not. Relative changes in BPE % are most predictive of women who develop breast cancer after RRSO (p < 0.05), while combining BPE % and |FGT| yields an AUC of 0.80, higher than BPE % (AUC = 0.78) or |FGT| (AUC = 0.66) alone (both p > 0.02). Quantitative measures of BPE and FGT are different before and after RRSO, and their relative changes are associated with prediction of developing breast cancer, potentially indicative of women who are more susceptible to develop breast cancer after RRSO in BRCA1/2 mutation carriers. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Science communicators (journalists, bloggers, editors) | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 21% |
| Researcher | 13 | 19% |
| Student > Postgraduate | 6 | 9% |
| Student > Master | 5 | 7% |
| Other | 4 | 6% |
| Other | 7 | 10% |
| Unknown | 20 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 23% |
| Engineering | 6 | 9% |
| Physics and Astronomy | 4 | 6% |
| Nursing and Health Professions | 4 | 6% |
| Computer Science | 4 | 6% |
| Other | 10 | 14% |
| Unknown | 26 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2021.
All research outputs
#6,443,738
of 25,374,647 outputs
Outputs from Breast Cancer Research
#736
of 2,053 outputs
Outputs of similar age
#70,063
of 280,057 outputs
Outputs of similar age from Breast Cancer Research
#10
of 37 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,057 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.