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Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo.

Overview of attention for article published in Oncotarget, May 2015
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Title
Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo.
Published in
Oncotarget, May 2015
DOI 10.18632/oncotarget.4038
Pubmed ID
Authors

Abrahamsson, Annelie, Dabrosin, Charlotta

Abstract

Extracellular circulating microRNAs (miRNAs) have been suggested to be biomarkers for disease monitoring but data are inconsistent, one reason being that blood miRNA is of heterogeneous origin. Here, we sampled extracellular microRNAs locally in situ using microdialysis. Three different cohorts of women were included; postmenopausal women with ongoing breast cancer investigated within the cancer and in normal adjacent breast tissue, postmenopausal women investigated in their normal healthy breast and subcutaneous fat before and after six weeks of tamoxifen therapy, premenopausal women during the menstrual cycle. Samples were initially screened using TaqMan array cards with subsequently absolute quantification. 124 miRNA were expressed in microdialysates. After absolute quantifications extracellular miRNA-21 was found to be significantly increased in breast cancer. In addition, the levels were significantly higher in pre-menopausal breast tissue compared with postmenopausal. In breast tissue of pre-menopausal women miRNA-21 exhibited a cyclic variation during the menstrual cycle and in postmenopausal women six weeks of tamoxifen treatment decreased miRNA-21 suggesting that this miRNA may be important for breast carcinogenesis. None of these changes were found in plasma or microdialysates from subcutaneous fat. Our data revealed tissue specific changes of extracellular circulating miRNAs that would be otherwise unraveled using blood samples.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 25%
Unknown 3 75%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 50%
Professor 1 25%
Researcher 1 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 50%
Pharmacology, Toxicology and Pharmaceutical Science 1 25%
Biochemistry, Genetics and Molecular Biology 1 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2015.
All research outputs
#4,285,503
of 5,154,018 outputs
Outputs from Oncotarget
#2,512
of 4,101 outputs
Outputs of similar age
#142,320
of 173,105 outputs
Outputs of similar age from Oncotarget
#161
of 232 outputs
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