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Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis

Overview of attention for article published in Anais brasileiros de dermatologia, March 2018
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Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis
Published in
Anais brasileiros de dermatologia, March 2018
DOI 10.1590/abd1806-4841.20186340
Pubmed ID

Marilene Chaves Silvestre, Maria Notomi Sato, Vitor Manoel Silva dos Reis


Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TNF, IL-1β, and IL-18, contributing to the development of Allergic Contact Dermatitis. Dendritic cells recognize and process antigenic peptides into T cells. Neutrophils cause pro-inflammatory reactions, mast cells induce migration/maturation of skin DCs, the natural killer cells have natural cytotoxic capacity, the γδ T cells favor contact with hapten during the sensitization phase, and the innate lymphoid cells act in the early stages by secreting cytokines, as well as act in inflammation and tissue homeostasis. The antigen-specific inflammation is mediated by T cells, and each subtype of T cells (Th1/Tc1, Th2/Tc2, and Th17/Tc17) activates resident skin cells, thus contributing to inflammation. Skin's regulatory T cells have a strong ability to inhibit the proliferation of hapten-specific T cells, acting at the end of the Allergic Contact Dermatitis response and in the control of systemic immune responses. In this review, we report how cutaneous innate immunity is the first line of defense and focus its role in the activation of the adaptive immune response, with effector response induction and its regulation.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 13%
Student > Bachelor 9 13%
Student > Postgraduate 8 11%
Student > Master 7 10%
Student > Ph. D. Student 7 10%
Other 7 10%
Unknown 23 33%
Readers by discipline Count As %
Medicine and Dentistry 16 23%
Immunology and Microbiology 9 13%
Agricultural and Biological Sciences 7 10%
Biochemistry, Genetics and Molecular Biology 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 5 7%
Unknown 27 39%