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Lipids containing medium-chain fatty acids are specific to post-whole genome duplication Saccharomycotina yeasts

Overview of attention for article published in BMC Evolutionary Biology, May 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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5 tweeters
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2 patents

Citations

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11 Dimensions

Readers on

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36 Mendeley
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Title
Lipids containing medium-chain fatty acids are specific to post-whole genome duplication Saccharomycotina yeasts
Published in
BMC Evolutionary Biology, May 2015
DOI 10.1186/s12862-015-0369-2
Pubmed ID
Authors

Marine Froissard, Michel Canonge, Marie Pouteaux, Bernard Cintrat, Sabrina Mohand-Oumoussa, Stéphane E. Guillouet, Thierry Chardot, Noémie Jacques, Serge Casaregola

Abstract

Yeasts belonging to the subphylum Saccharomycotina have been used for centuries in food processing and, more recently, biotechnology. Over the past few decades, these yeasts have also been studied in the interest of their potential to produce oil to replace fossil resources. Developing yeasts for massive oil production requires increasing yield and modifying the profiles of the fatty acids contained in the oil to satisfy specific technical requirements. For example, derivatives of medium-chain fatty acids (MCFAs, containing 6-14 carbons) are used for the production of biodiesels, cleaning products, lubricants and cosmetics. Few studies are available in the literature on the production of MCFAs in yeasts. We analyzed the MCFA content in Saccharomyces cerevisiae grown in various conditions. The results revealed that MCFAs preferentially accumulated when cells were grown on synthetic media with a high C/N ratio at low temperature (23 °C). Upon screening deletion mutant strains for genes encoding lipid droplet-associated proteins, we found two genes, LOA1 and TGL3, involved in MCFA homeostasis. A phylogenetic analysis on 16 Saccharomycotina species showed that fatty acid profiles differed drastically among yeasts. Interestingly, MCFAs are only present in post-whole genome duplication yeast species. In this study, we produced original data on fatty acid diversity in yeasts. We demonstrated that yeasts are amenable to genetic and metabolic engineering to increase their MCFA production. Furthermore, we revealed that yeast lipid biodiversity has not been fully explored, but that yeasts likely harbor as-yet-undiscovered strains or enzymes that can contribute to the production of high-value fatty acids for green chemistry.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 25%
Researcher 9 25%
Professor > Associate Professor 4 11%
Student > Master 4 11%
Student > Bachelor 3 8%
Other 3 8%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 53%
Biochemistry, Genetics and Molecular Biology 7 19%
Chemistry 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Medicine and Dentistry 1 3%
Other 1 3%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2016.
All research outputs
#1,376,611
of 9,365,896 outputs
Outputs from BMC Evolutionary Biology
#588
of 2,132 outputs
Outputs of similar age
#41,334
of 224,136 outputs
Outputs of similar age from BMC Evolutionary Biology
#27
of 64 outputs
Altmetric has tracked 9,365,896 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,132 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,136 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.