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Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis

Overview of attention for article published in The American Journal of Tropical Medicine and Hygiene, April 2018
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Title
Exhaled Nitric Oxide is Not a Biomarker for Pulmonary Tuberculosis
Published in
The American Journal of Tropical Medicine and Hygiene, April 2018
DOI 10.4269/ajtmh.17-0425
Pubmed ID
Authors

José W. López, Maria-Cristina I. Loader, Daniel Smith, Daniel Pastorius, Marjory Bravard, Luz Caviedes, Karina M. Romero, Taryn Clark, William Checkley, Eduardo Ticona, Jon S. Friedland, Robert H. Gilman

Abstract

To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, noninvasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multidrug resistant-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion [ppb] [interquartile range (IQR) = 8-26] versus 15 ppb [IQR = 12-24]), and there was no change over 60 days of treatment (15 ppb [IQR = 10-19] at day 60). Taking this and previous evidence together, we conclude FeNO is not of value in either the diagnosis of pulmonary TB or as a marker of treatment response.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 18%
Student > Master 5 15%
Student > Bachelor 4 12%
Student > Ph. D. Student 4 12%
Professor > Associate Professor 3 9%
Other 6 18%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 19 56%
Immunology and Microbiology 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Agricultural and Biological Sciences 1 3%
Other 2 6%
Unknown 6 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2018.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from The American Journal of Tropical Medicine and Hygiene
#7,613
of 9,524 outputs
Outputs of similar age
#219,533
of 339,863 outputs
Outputs of similar age from The American Journal of Tropical Medicine and Hygiene
#66
of 121 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,524 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,863 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.