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Structural and functional features of central nervous system lymphatic vessels

Overview of attention for article published in Nature, June 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

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965 Dimensions

Readers on

mendeley
2470 Mendeley
citeulike
7 CiteULike
Title
Structural and functional features of central nervous system lymphatic vessels
Published in
Nature, June 2015
DOI 10.1038/nature14432
Pubmed ID
Authors

Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris, Jonathan Kipnis

Abstract

One of the characteristics of the central nervous system is the lack of a classical lymphatic drainage system. Although it is now accepted that the central nervous system undergoes constant immune surveillance that takes place within the meningeal compartment, the mechanisms governing the entrance and exit of immune cells from the central nervous system remain poorly understood. In searching for T-cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the cerebrospinal fluid, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the central nervous system. The discovery of the central nervous system lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

Twitter Demographics

The data shown below were collected from the profiles of 1,210 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 2,470 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 64 3%
United Kingdom 26 1%
Germany 16 <1%
Japan 8 <1%
Spain 8 <1%
Canada 8 <1%
Italy 6 <1%
Denmark 6 <1%
China 6 <1%
Other 56 2%
Unknown 2266 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 582 24%
Researcher 527 21%
Student > Master 292 12%
Student > Bachelor 286 12%
Student > Doctoral Student 172 7%
Other 611 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 756 31%
Medicine and Dentistry 570 23%
Neuroscience 330 13%
Unspecified 198 8%
Biochemistry, Genetics and Molecular Biology 158 6%
Other 458 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2077. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2018.
All research outputs
#525
of 12,146,908 outputs
Outputs from Nature
#98
of 61,717 outputs
Outputs of similar age
#10
of 232,927 outputs
Outputs of similar age from Nature
#5
of 1,006 outputs
Altmetric has tracked 12,146,908 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 61,717 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 73.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,927 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,006 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.