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Structural and functional features of central nervous system lymphatics

Overview of attention for article published in Nature, June 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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mendeley
1775 Mendeley
citeulike
7 CiteULike
Title
Structural and functional features of central nervous system lymphatics
Published in
Nature, June 2015
DOI 10.1038/nature14432
Pubmed ID
Authors

Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris, Jonathan Kipnis, Louveau, Antoine, Smirnov, Igor, Keyes, Timothy J, Eccles, Jacob D, Rouhani, Sherin J, Peske, J David, Derecki, Noel C, Castle, David, Mandell, James W, Lee, Kevin S, Harris, Tajie H, Kipnis, Jonathan, S. Lee Kevin

Abstract

One of the characteristics of the central nervous system is the lack of a classical lymphatic drainage system. Although it is now accepted that the central nervous system undergoes constant immune surveillance that takes place within the meningeal compartment, the mechanisms governing the entrance and exit of immune cells from the central nervous system remain poorly understood. In searching for T-cell gateways into and out of the meninges, we discovered functional lymphatic vessels lining the dural sinuses. These structures express all of the molecular hallmarks of lymphatic endothelial cells, are able to carry both fluid and immune cells from the cerebrospinal fluid, and are connected to the deep cervical lymph nodes. The unique location of these vessels may have impeded their discovery to date, thereby contributing to the long-held concept of the absence of lymphatic vasculature in the central nervous system. The discovery of the central nervous system lymphatic system may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 1,775 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 62 3%
United Kingdom 21 1%
Germany 12 <1%
Canada 8 <1%
Spain 8 <1%
Japan 7 <1%
Italy 6 <1%
France 6 <1%
Denmark 5 <1%
Other 50 3%
Unknown 1590 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 427 24%
Researcher 363 20%
Student > Master 220 12%
Student > Bachelor 188 11%
Student > Doctoral Student 110 6%
Other 337 19%
Unknown 130 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 701 39%
Medicine and Dentistry 426 24%
Neuroscience 156 9%
Psychology 69 4%
Biochemistry, Genetics and Molecular Biology 60 3%
Other 233 13%
Unknown 130 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1671. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2017.
All research outputs
#451
of 7,942,525 outputs
Outputs from Nature
#120
of 46,772 outputs
Outputs of similar age
#15
of 220,081 outputs
Outputs of similar age from Nature
#6
of 1,004 outputs
Altmetric has tracked 7,942,525 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,772 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 72.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,081 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,004 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.