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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular pathway of near-infrared laser phototoxicity involves ATF-4 orchestrated ER stress
|
|---|---|
| Published in |
Scientific Reports, June 2015
|
| DOI | 10.1038/srep10581 |
| Pubmed ID | |
| Authors |
Imran Khan, Elieza Tang, Praveen Arany |
| Abstract |
High power lasers are used extensively in medicine while lower power applications are popular for optical imaging, optogenetics, skin rejuvenation and a therapeutic modality termed photobiomodulation (PBM). This study addresses the therapeutic dose limits, biological safety and molecular pathway of near-infrared (NIR) laser phototoxicity. Increased erythema and tissue damage were noted in mice skin and cytotoxicity in cell cultures at phototoxic laser doses involving generation of reactive oxygen species (ROS) coupled with a rise in surface temperature (>45 °C). NIR laser phototoxicity results from Activating Transcription Factor-4 (ATF-4) mediated endoplasmic reticulum stress and autophagy. Neutralizations of heat or ROS and overexpressing ATF-4 were noted to rescue NIR laser phototoxicity. Further, NIR laser mediated phototoxicity was noted to be non-genotoxic and non-mutagenic. This study outlines the mechanism of NIR laser phototoxicity and the utility of monitoring surface temperature and ATF4 expression as potential biomarkers to develop safe and effective clinical applications. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 1% |
| Unknown | 86 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 22% |
| Student > Ph. D. Student | 15 | 17% |
| Student > Master | 15 | 17% |
| Student > Doctoral Student | 5 | 6% |
| Other | 5 | 6% |
| Other | 16 | 18% |
| Unknown | 12 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 28% |
| Physics and Astronomy | 10 | 11% |
| Agricultural and Biological Sciences | 9 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Engineering | 5 | 6% |
| Other | 18 | 21% |
| Unknown | 15 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2016.
All research outputs
#15,334,706
of 22,808,725 outputs
Outputs from Scientific Reports
#77,632
of 123,118 outputs
Outputs of similar age
#157,038
of 267,542 outputs
Outputs of similar age from Scientific Reports
#1,059
of 1,737 outputs
Altmetric has tracked 22,808,725 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 123,118 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,542 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,737 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.