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Mutations in the p53 gene occur in diverse human tumour types

Overview of attention for article published in Nature, December 1989
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

Mentioned by

blogs
1 blog
policy
1 policy source
patent
42 patents
wikipedia
1 Wikipedia page

Citations

dimensions_citation
2184 Dimensions

Readers on

mendeley
239 Mendeley
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Title
Mutations in the p53 gene occur in diverse human tumour types
Published in
Nature, December 1989
DOI 10.1038/342705a0
Pubmed ID
Authors

Janice M. Nigro, Suzanne J. Baker, Antonette C. Preisinger, J. Milburn Jessup, Richard Hosteller, Karen Cleary, Sandra H. Signer, Nancy Davidson, Stephen Baylin, Peter Devilee, Thomas Glover, Francis S. Collins, Ainsley Weslon, Rama Modali, Curtis C. Harris, Bert Vogelstein

Abstract

The p53 gene has been a constant source of fascination since its discovery nearly a decade ago. Originally considered to be an oncogene, several convergent lines of research have indicated that the wild-type gene product actually functions as a tumour suppressor gene. For example, expression of the neoplastic phenotype is inhibited, rather than promoted, when rat cells are transfected with the murine wild-type p53 gene together with mutant p53 genes and/or other oncogenes. Moreover, in human tumours, the short arm of chromosome 17 is often deleted. In colorectal cancers, the smallest common region of deletion is centred at 17p13.1; this region harbours the p53 gene, and in two tumours examined in detail, the remaining (non-deleted) p53 alleles were found to contain mutations. This result was provocative because allelic deletion coupled with mutation of the remaining allele is a theoretical hallmark of tumour-suppressor genes. In the present report, we have attempted to determine the generality of this observation; that is, whether tumours with allelic deletions of chromosome 17p contain mutant p53 genes in the allele that is retained. Our results suggest that (1) most tumours with such allelic deletions contain p53 point mutations resulting in amino-acid substitutions, (2) such mutations are not confined to tumours with allelic deletion, but also occur in at least some tumours that have retained both parental 17p alleles, and (3) p53 gene mutations are clustered in four 'hot-spots' which exactly coincide with the four most highly conserved regions of the gene. These results suggest that p53 mutations play a role in the development of many common human malignancies.

Mendeley readers

The data shown below were compiled from readership statistics for 239 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
United States 2 <1%
Denmark 2 <1%
Canada 2 <1%
Brazil 1 <1%
Italy 1 <1%
Japan 1 <1%
Malaysia 1 <1%
Serbia 1 <1%
Other 0 0%
Unknown 226 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 26%
Student > Bachelor 41 17%
Researcher 30 13%
Student > Master 30 13%
Student > Doctoral Student 16 7%
Other 39 16%
Unknown 22 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 65 27%
Medicine and Dentistry 58 24%
Biochemistry, Genetics and Molecular Biology 58 24%
Engineering 9 4%
Chemistry 9 4%
Other 15 6%
Unknown 25 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2019.
All research outputs
#805,950
of 14,848,875 outputs
Outputs from Nature
#26,729
of 73,282 outputs
Outputs of similar age
#5,118
of 111,511 outputs
Outputs of similar age from Nature
#455
of 945 outputs
Altmetric has tracked 14,848,875 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 73,282 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 82.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,511 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 945 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.