Title |
Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection
|
---|---|
Published in |
Infection and Immunity, June 2015
|
DOI | 10.1128/iai.00226-15 |
Pubmed ID | |
Authors |
Steven Kho, Jutta Marfurt, Rintis Noviyanti, Andreas Kusuma, Kim A. Piera, Faustina H. Burdam, Enny Kenangalem, Daniel A. Lampah, Christian R. Engwerda, Jeanne R. Poespoprodjo, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Tonia Woodberry |
Abstract |
Clinical illness with P. falciparum or P. vivax compromises dendritic cell (DC) function and expands regulatory T (Treg) cells. Individuals with asymptomatic parasitemia have clinical immunity restricting parasite expansion and preventing clinical disease. The role of DC and Treg cells during asymptomatic Plasmodium infection is unclear. During a cross-sectional household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC, CD141+ or CD1c+ myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (15 P. falciparum and 36 P. vivax infections) and 162 afebrile adults (20 P. falciparum and 20 P. vivax infections), alongside samples from 16 patients hospitalised with uncomplicated malaria. Unlike malaria patients, DC from children and adults with asymptomatic microscopy-positive P. vivax or P. falciparum infection increased or retained HLA-DR expression. Treg cells in asymptomatic adults and children exhibited reduced activation, suggesting increased immune responsiveness. In asymptomatic infection pDC and mDC subsets varied according to clinical immunity (asymptomatic or symptomatic Plasmodium infection), host age and parasite species. In conclusion, active control of asymptomatic infection was associated with, and likely contingent upon, functional DC and reduced Treg cell activation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Peru | 1 | 2% |
Unknown | 59 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 11 | 18% |
Student > Ph. D. Student | 9 | 15% |
Student > Master | 7 | 11% |
Researcher | 5 | 8% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 13% |
Unknown | 17 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 21% |
Immunology and Microbiology | 10 | 16% |
Agricultural and Biological Sciences | 7 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Unspecified | 3 | 5% |
Other | 7 | 11% |
Unknown | 18 | 30% |