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Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection

Overview of attention for article published in Infection and Immunity, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

twitter
5 tweeters

Citations

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24 Dimensions

Readers on

mendeley
48 Mendeley
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Title
Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection
Published in
Infection and Immunity, August 2015
DOI 10.1128/iai.00226-15
Pubmed ID
Authors

Steven Kho, Jutta Marfurt, Rintis Noviyanti, Andreas Kusuma, Kim A. Piera, Faustina H. Burdam, Enny Kenangalem, Daniel A. Lampah, Christian R. Engwerda, Jeanne R. Poespoprodjo, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Tonia Woodberry

Abstract

Clinical illness with P. falciparum or P. vivax compromises dendritic cell (DC) function and expands regulatory T (Treg) cells. Individuals with asymptomatic parasitemia have clinical immunity restricting parasite expansion and preventing clinical disease. The role of DC and Treg cells during asymptomatic Plasmodium infection is unclear. During a cross-sectional household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC, CD141+ or CD1c+ myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (15 P. falciparum and 36 P. vivax infections) and 162 afebrile adults (20 P. falciparum and 20 P. vivax infections), alongside samples from 16 patients hospitalised with uncomplicated malaria. Unlike malaria patients, DC from children and adults with asymptomatic microscopy-positive P. vivax or P. falciparum infection increased or retained HLA-DR expression. Treg cells in asymptomatic adults and children exhibited reduced activation, suggesting increased immune responsiveness. In asymptomatic infection pDC and mDC subsets varied according to clinical immunity (asymptomatic or symptomatic Plasmodium infection), host age and parasite species. In conclusion, active control of asymptomatic infection was associated with, and likely contingent upon, functional DC and reduced Treg cell activation.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Peru 1 2%
Unknown 46 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 21%
Student > Ph. D. Student 8 17%
Student > Master 7 15%
Researcher 5 10%
Student > Doctoral Student 4 8%
Other 4 8%
Unknown 10 21%
Readers by discipline Count As %
Medicine and Dentistry 12 25%
Immunology and Microbiology 9 19%
Agricultural and Biological Sciences 7 15%
Biochemistry, Genetics and Molecular Biology 3 6%
Computer Science 2 4%
Other 4 8%
Unknown 11 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2015.
All research outputs
#6,570,087
of 12,359,213 outputs
Outputs from Infection and Immunity
#3,948
of 5,688 outputs
Outputs of similar age
#89,320
of 233,812 outputs
Outputs of similar age from Infection and Immunity
#30
of 132 outputs
Altmetric has tracked 12,359,213 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,688 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,812 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 132 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.