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Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection

Overview of attention for article published in Infection and Immunity, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Citations

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61 Mendeley
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Title
Preserved Dendritic Cell HLA-DR Expression and Reduced Regulatory T Cell Activation in Asymptomatic Plasmodium falciparum and P. vivax Infection
Published in
Infection and Immunity, June 2015
DOI 10.1128/iai.00226-15
Pubmed ID
Authors

Steven Kho, Jutta Marfurt, Rintis Noviyanti, Andreas Kusuma, Kim A. Piera, Faustina H. Burdam, Enny Kenangalem, Daniel A. Lampah, Christian R. Engwerda, Jeanne R. Poespoprodjo, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo, Tonia Woodberry

Abstract

Clinical illness with P. falciparum or P. vivax compromises dendritic cell (DC) function and expands regulatory T (Treg) cells. Individuals with asymptomatic parasitemia have clinical immunity restricting parasite expansion and preventing clinical disease. The role of DC and Treg cells during asymptomatic Plasmodium infection is unclear. During a cross-sectional household survey in Papua, Indonesia, we examined the number and activation of blood plasmacytoid DC, CD141+ or CD1c+ myeloid DC (mDC) subsets and Treg cells using flow cytometry in 168 afebrile children (15 P. falciparum and 36 P. vivax infections) and 162 afebrile adults (20 P. falciparum and 20 P. vivax infections), alongside samples from 16 patients hospitalised with uncomplicated malaria. Unlike malaria patients, DC from children and adults with asymptomatic microscopy-positive P. vivax or P. falciparum infection increased or retained HLA-DR expression. Treg cells in asymptomatic adults and children exhibited reduced activation, suggesting increased immune responsiveness. In asymptomatic infection pDC and mDC subsets varied according to clinical immunity (asymptomatic or symptomatic Plasmodium infection), host age and parasite species. In conclusion, active control of asymptomatic infection was associated with, and likely contingent upon, functional DC and reduced Treg cell activation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Peru 1 2%
Unknown 59 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 18%
Student > Ph. D. Student 9 15%
Student > Master 7 11%
Researcher 5 8%
Student > Doctoral Student 4 7%
Other 8 13%
Unknown 17 28%
Readers by discipline Count As %
Medicine and Dentistry 13 21%
Immunology and Microbiology 10 16%
Agricultural and Biological Sciences 7 11%
Biochemistry, Genetics and Molecular Biology 3 5%
Unspecified 3 5%
Other 7 11%
Unknown 18 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2015.
All research outputs
#14,914,476
of 25,373,627 outputs
Outputs from Infection and Immunity
#11,231
of 13,521 outputs
Outputs of similar age
#133,875
of 281,411 outputs
Outputs of similar age from Infection and Immunity
#32
of 94 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,521 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,411 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.