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Supragingival biofilm control and systemic inflammation in patients with type 2 diabetes mellitus

Overview of attention for article published in Brazilian Oral Research, June 2015
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Title
Supragingival biofilm control and systemic inflammation in patients with type 2 diabetes mellitus
Published in
Brazilian Oral Research, June 2015
DOI 10.1590/1807-3107bor-2015.vol29.0071
Pubmed ID
Authors

Hilana Paula Carillo ARTESE, Priscila Larcher LONGO, Giovane Hisse GOMES, Marcia Pinto Alves MAYER, Giuseppe Alexandre ROMITO

Abstract

The objective of this study was to evaluate the effect of strict supragingival biofilm control on serum inflammatory markers and on periodontal clinical parameters in type 2 diabetes mellitus (T2DM) patients with chronic severe periodontitis. Twenty-four individuals with T2DM and periodontitis were randomly allocated to two treatment groups. The supragingival therapy group (ST, n = 12) received supragingival scaling, whereas the intensive therapy group (IT, n = 12) underwent supra- and subgingival scaling, as well as root planing. Patients from both groups received professional oral hygiene instructions every month. Data regarding visible plaque index (VPI), gingival bleeding index (GBI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), serum levels of interleukin (IL)-6, IL-17A, IL-8, tumor necrosis factor α (TNF-α), monocyte chemoattractant protein (MCP)-1 enzyme-linked immunosorbent assay (ELISA), and glycated hemoglobin (HbA1c) levels were obtained at baseline and at 6 months post-therapy. Both therapies resulted in the improvement of almost all clinical periodontal parameters (p < 0.05). There were no differences in TNF-α, IL-8, IL-17A and HbA1c levels in either group (p > 0.05), between the two periods. However, MCP-1 levels were significantly reduced in both the ST (p = 0.034) and the IT (p = 0.016) groups, whereas the serum IL-6 levels were significantly reduced only in the IT group (p = 0.001). Strict control of supragingival biofilm has a limited effect on systemic inflammatory markers, and a moderate effect on periodontal clinical parameters.

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Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 107 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 31 29%
Student > Master 13 12%
Student > Ph. D. Student 12 11%
Student > Postgraduate 10 9%
Student > Doctoral Student 6 6%
Other 16 15%
Unknown 19 18%
Readers by discipline Count As %
Medicine and Dentistry 65 61%
Nursing and Health Professions 6 6%
Biochemistry, Genetics and Molecular Biology 4 4%
Agricultural and Biological Sciences 3 3%
Immunology and Microbiology 2 2%
Other 6 6%
Unknown 21 20%