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Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

Overview of attention for article published in Nature Reviews Immunology, October 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

blogs
1 blog
twitter
4 X users
patent
35 patents
facebook
1 Facebook page

Citations

dimensions_citation
1603 Dimensions

Readers on

mendeley
1368 Mendeley
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1 CiteULike
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1 Connotea
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Title
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Published in
Nature Reviews Immunology, October 2010
DOI 10.1038/nri2868
Pubmed ID
Authors

Martin F. Bachmann, Gary T. Jennings

Abstract

Researchers working on the development of vaccines face an inherent dilemma: to maximize immunogenicity without compromising safety and tolerability. Early vaccines often induced long-lived protective immune responses, but tolerability was a major problem. Newer vaccines have very few side effects but can be of limited immunogenicity. One way to tackle this problem is to design vaccines that have all the properties of pathogens with the exception of causing disease. Key features of pathogens that can be mimicked by vaccine delivery systems are their size, shape and surface molecule organization. In addition, pathogen-associated molecular patterns can be used to induce innate immune responses that promote adaptive immunity. In this Review, we discuss the approaches currently being used to optimize the delivery of antigens and enhance vaccine efficacy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,368 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 8 <1%
Germany 4 <1%
United Kingdom 4 <1%
Switzerland 2 <1%
France 2 <1%
Chile 1 <1%
Ireland 1 <1%
Kenya 1 <1%
Australia 1 <1%
Other 9 <1%
Unknown 1335 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 343 25%
Researcher 189 14%
Student > Master 154 11%
Student > Bachelor 133 10%
Student > Doctoral Student 69 5%
Other 163 12%
Unknown 317 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 256 19%
Biochemistry, Genetics and Molecular Biology 194 14%
Immunology and Microbiology 145 11%
Pharmacology, Toxicology and Pharmaceutical Science 87 6%
Medicine and Dentistry 82 6%
Other 249 18%
Unknown 355 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
All research outputs
#1,427,632
of 23,332,901 outputs
Outputs from Nature Reviews Immunology
#611
of 2,508 outputs
Outputs of similar age
#4,925
of 100,341 outputs
Outputs of similar age from Nature Reviews Immunology
#5
of 19 outputs
Altmetric has tracked 23,332,901 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,508 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.9. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,341 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.