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Characterization of a G1P[8] rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era

Overview of attention for article published in Emerging Microbes & Infections, January 2019
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Title
Characterization of a G1P[8] rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era
Published in
Emerging Microbes & Infections, January 2019
DOI 10.1038/emi.2014.47
Pubmed ID
Authors

Celeste M Donato, Daniel Cowley, Thomas L Snelling, Asmik Akopov, Ewen F Kirkness, Carl D Kirkwood

Abstract

In 2010, a large outbreak of rotavirus gastroenteritis occurred in the Alice Springs region of the Northern Territory, Australia. The outbreak occurred 43 months after the introduction of the G1P[8] rotavirus vaccine Rotarix(®). Forty-three infants were hospitalized during the outbreak and analysis of fecal samples from each infant revealed a G1P[8] rotavirus strain. The outbreak strain was adapted to cell culture and neutralization assays were performed using VP7 and VP4 neutralizing monoclonal antibodies. The outbreak strain exhibited a distinct neutralization resistance pattern compared to the Rotarix(®) vaccine strain. Whole genome sequencing of the 2010 outbreak virus strain demonstrated numerous amino acid differences compared to the Rotarix(®) vaccine strain in the characterized neutralization epitopes of the VP7 and VP4 proteins. Phylogenetic analysis of the outbreak strain revealed a close genetic relationship to global strains, in particular RVA/Human-wt/BEL/BE0098/2009/G1P[8] and RVA/Human-wt/BEL/BE00038/2008/G1P[8] for numerous genes. The 2010 outbreak strain was likely introduced from a globally circulating population of strains rather than evolving from an endemic Australian strain. The outbreak strain possessed antigenic differences in the VP7 and VP4 proteins compared to the Rotarix(®) vaccine strain. The outbreak was associated with moderate vaccine coverage and possibly low vaccine take in the population.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 5%
South Africa 1 5%
Unknown 20 91%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 27%
Student > Ph. D. Student 5 23%
Student > Master 4 18%
Researcher 4 18%
Professor > Associate Professor 2 9%
Other 1 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 32%
Medicine and Dentistry 4 18%
Biochemistry, Genetics and Molecular Biology 4 18%
Unspecified 2 9%
Nursing and Health Professions 1 5%
Other 4 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2015.
All research outputs
#6,439,311
of 7,435,338 outputs
Outputs from Emerging Microbes & Infections
#116
of 134 outputs
Outputs of similar age
#182,311
of 216,925 outputs
Outputs of similar age from Emerging Microbes & Infections
#8
of 8 outputs
Altmetric has tracked 7,435,338 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 134 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one.